Oz S Gul, Fentoglu Ozlem, Kilicarslan Alpaslan, Guven Gulay Sain, Tanrtover Mine Durusu, Aykac Yasar, Sozen Tumay
Hacettepe University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey.
South Med J. 2007 Jul;100(7):686-91. doi: 10.1097/SMJ.0b013e31802fa327.
The authors aimed to evaluate whether local periodontal therapy may influence plasma lipid levels in patients with periodontitis.
Fifty patients (31 females and 19 males, age 36-66 yr) were randomly assigned to the treatment and control groups. Lipid profile and dental variables were measured at baseline and at the end of the study in both groups.
In the third month, there was a significant decrease in total and low density lipoprotein (LDL) cholesterol levels of the treatment group compared with baseline values. Also, the reduction in bleeding on probing, pocket depth, attachment loss, plaque index and gingival index were statistically significant in the treatment group.
The present study indicates that periodontitis causes changes in total and LDL cholesterol levels and local periodontal treatment resulted in a significant decrease in these markers. These results suggest a potential effect of periodontitis-driven systemic inflammation on lipid metabolism.
作者旨在评估局部牙周治疗是否会影响牙周炎患者的血脂水平。
50名患者（31名女性和19名男性，年龄36 - 66岁）被随机分为治疗组和对照组。在两组的基线和研究结束时测量血脂谱和牙科变量。
在第三个月，与基线值相比，治疗组的总胆固醇和低密度脂蛋白（LDL）胆固醇水平显著降低。此外，治疗组在探诊出血、牙周袋深度、附着丧失、菌斑指数和牙龈指数方面的降低具有统计学意义。
本研究表明，牙周炎会导致总胆固醇和LDL胆固醇水平发生变化，局部牙周治疗导致这些指标显著降低。这些结果提示牙周炎驱动的全身炎症对脂质代谢具有潜在影响。
