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Rapid synthesis of iminosugar derivatives for cell-based in situ screening: discovery of "hit" compounds with anticancer activity.

作者信息

Zhang Lei, Sun Fang, Li Yingxia, Sun Xue, Liu Xiaomin, Huang Yingshen, Zhang Li-He, Ye Xin-Shan, Xiao Junjun

机构信息

The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd #38, Beijing 100083, China.

出版信息

ChemMedChem. 2007 Nov;2(11):1594-7. doi: 10.1002/cmdc.200700120.

DOI:10.1002/cmdc.200700120
PMID:17639998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7162357/
Abstract
摘要

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本文引用的文献

1
Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.用于戈谢病干预的基于异法戈明和2,5-脱水-2,5-亚氨基-D-葡萄糖醇的葡萄糖脑苷脂酶药理学伴侣分子。
J Med Chem. 2007 Jan 11;50(1):94-100. doi: 10.1021/jm060677i.
2
Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants.化学伴侣和允许温度改变了与戈谢病相关的葡萄糖脑苷脂酶变体的定位。
ACS Chem Biol. 2006 May 23;1(4):235-51. doi: 10.1021/cb600187q.
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Glycosylation pathways as drug targets for cancer: glycosidase inhibitors.
Mini Rev Med Chem. 2006 Sep;6(9):1043-52. doi: 10.2174/138955706778195162.
4
Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.稳定的苯并三唑酯作为严重急性呼吸综合征3CL蛋白酶的基于机制的失活剂。
Chem Biol. 2006 Mar;13(3):261-8. doi: 10.1016/j.chembiol.2005.12.008.
5
Microtiter plate based chemistry and in situ screening: a useful approach for rapid inhibitor discovery.基于微量滴定板的化学方法和原位筛选:一种快速发现抑制剂的有效方法。
Org Biomol Chem. 2006 Apr 21;4(8):1446-57. doi: 10.1039/b600055j. Epub 2006 Mar 22.
6
Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ.四丁基氟化铵介导的微孔板快速烷基化反应用于原位发现酶抑制剂。
Chembiochem. 2005 Dec;6(12):2176-80. doi: 10.1002/cbic.200500295.
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Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells.功能化吡咯烷抑制人胶质母细胞瘤和黑色素瘤细胞的α-甘露糖苷酶活性及生长。
J Med Chem. 2005 Jun 30;48(13):4237-46. doi: 10.1021/jm0409019.
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Synthetic iminosugar derivatives as new potential immunosuppressive agents.合成亚氨基糖衍生物作为新型潜在免疫抑制剂。
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Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ.通过组合皮克特-施彭格勒反应生成新型炭疽致死因子抑制剂并进行原位筛选。
Chembiochem. 2005 Jun;6(6):1002-6. doi: 10.1002/cbic.200500009.
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Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.α-岩藻糖苷酶皮摩尔级慢紧密结合抑制剂的发现。
Chem Biol. 2004 Sep;11(9):1301-6. doi: 10.1016/j.chembiol.2004.07.009.