Wong Samuel Y S, Lau Winny W Y, Leung Ping C, Leung Jason C S, Woo Jean
Department of Community and Family Medicine, School of Public Health, Prince of Wales Hospital, Shatin, N.T., Hong Kong.
Br J Nutr. 2007 Dec;98(6):1237-42. doi: 10.1017/S0007114507787433. Epub 2007 Jul 19.
The objective of the present study is to explore the association between lower urinary tract symptoms (LUTS) and dietary isoflavone in elderly men. In a large prospective cohort of 2000 Chinese men, the association between dietary isoflavone and LUTS were studied using standardized structured questionnaires. Dietary intake was assessed by a modified version of the Block FFQ. LUTS were assessed by the Chinese version of the International Prostatic Symptoms Score. Demographic, lifestyle and other medical information were also collected and were adjusted for in the analysis. After excluding 299 men with history of bladder surgery, bladder or prostate cancer or who were current users of medication for urinary problems, the association between LUTS and dietary isoflavone was explored. A total of 96.2 % of subjects reported some consumption of genistein, glycitein or daidzein. In ordinal multinominal logistic regression, subjects with dietary total isoflavone of more than 5.1 mg were significantly less likely to suffer from more severe LUTS (dietary intake from 5.1 to 9.5 mg: OR 0.59; 95 % CI 0.44, 0.80; from 9.6 to 14.3 mg: OR 0.81; 95 % CI 0.61, 1.09; from 14.4 to 21.7 mg: OR 0.68; 95 % CI 0.51, 0.92; 21.8 mg and above: OR 0.73; 95 % CI 0.54, 0.98) after adjustment for covariates. In this cross-sectional study, we showed a strong inverse association between dietary intake of isoflavone and the risk of LUTS.
本研究的目的是探讨老年男性下尿路症状（LUTS）与膳食异黄酮之间的关联。在一个由2000名中国男性组成的大型前瞻性队列中，使用标准化结构化问卷研究了膳食异黄酮与LUTS之间的关联。膳食摄入量通过改良版的Block食物频率问卷进行评估。LUTS通过国际前列腺症状评分中文版进行评估。还收集了人口统计学、生活方式和其他医学信息，并在分析中进行了调整。在排除299名有膀胱手术史、膀胱癌或前列腺癌病史或正在使用治疗泌尿系统问题药物的男性后，探讨了LUTS与膳食异黄酮之间的关联。共有96.2%的受试者报告摄入过一些染料木黄酮、黄豆黄素或大豆苷元。在有序多项逻辑回归中，膳食总异黄酮摄入量超过5.1毫克的受试者患更严重LUTS的可能性显著降低（膳食摄入量为5.1至9.5毫克：比值比0.59；95%置信区间0.44, 0.80；9.6至14.3毫克：比值比0.81；95%置信区间0.61, 1.09；14.4至21.7毫克：比值比0.68；95%置信区间0.51, 0.92；21.8毫克及以上：比值比0.73；95%置信区间0.54, 0.98），在对协变量进行调整后。在这项横断面研究中，我们发现膳食异黄酮摄入量与LUTS风险之间存在强烈的负相关。
