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二胺会干扰艾氏腹水癌细胞质膜囊泡中L-鸟氨酸的转运。

Diamines interfere with the transport of L-ornithine in Ehrlich-cell plasma-membrane vesicles.

作者信息

Medina M A, Urdiales J L, Mates J M, Núñez de Castro I, Sánchez-Jiménez F

机构信息

Laboratorio de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Málaga, Spain.

出版信息

Biochem J. 1991 Dec 15;280 ( Pt 3)(Pt 3):825-7. doi: 10.1042/bj2800825.

DOI:10.1042/bj2800825
PMID:1764045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1130531/
Abstract
  1. L-Ornithine transport by plasma-membrane vesicles isolated from Ehrlich cells is Na(+)-independent and shows a saturable and a diffusional component. 2. Putrescine, histamine, 5-hydroxytryptamine and 2,3-diaminopropane at 55 microM concentration significantly inhibit 0.5 mM-L-ornithine transport at least for the first 10 min of incubation. 3. There is a trans-stimulatory effect of putrescine on L-ornithine transport.
摘要
  1. 从艾氏腹水癌细胞分离的质膜囊泡对L-鸟氨酸的转运不依赖于Na⁺，且呈现出饱和成分和扩散成分。2. 浓度为55微摩尔的腐胺、组胺、5-羟色胺和2,3-二氨基丙烷在孵育至少最初10分钟内可显著抑制0.5毫摩尔/升L-鸟氨酸的转运。3. 腐胺对L-鸟氨酸转运有反式刺激作用。

相似文献

1
Diamines interfere with the transport of L-ornithine in Ehrlich-cell plasma-membrane vesicles.二胺会干扰艾氏腹水癌细胞质膜囊泡中L-鸟氨酸的转运。
Biochem J. 1991 Dec 15;280 ( Pt 3)(Pt 3):825-7. doi: 10.1042/bj2800825.
2
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J Cell Biochem. 1985;29(2):105-13. doi: 10.1002/jcb.240290206.
3
Regulation by 1,4-diamines of the ornithine decarboxylase activity induced by ornithine in perifused tumor cells.
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4
Polyamines and their biosynthetic enzymes in Ehrlich ascites-carcinoma cells. Modification of tumour polyamine pattern by diamines.艾氏腹水癌细胞中的多胺及其生物合成酶。二胺对肿瘤多胺模式的改变。
Biochem J. 1977 Jul 15;166(1):89-94. doi: 10.1042/bj1660089.
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Regulation of L-ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase in rat ventral prostate and seminal vesicle.大鼠腹侧前列腺和精囊腺中L-鸟氨酸脱羧酶和S-腺苷-L-甲硫氨酸脱羧酶的调节
Biochem J. 1977 Dec 15;168(3):379-85. doi: 10.1042/bj1680379.

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AMMO-Prot: amine system project 3D-model finder.AMMO-Prot：胺系统项目3D模型查找器。
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Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines.氯苯那敏抑制鸟氨酸脱羧酶的合成及人乳腺癌细胞系的增殖。
Breast Cancer Res Treat. 1995 Aug;35(2):187-94. doi: 10.1007/BF00668208.

本文引用的文献

1
Cationic amino acid transport into cultured animal cells. II. Transport system barely perceptible in ordinary hepatocytes, but active in hepatoma cell lines.阳离子氨基酸转运进入培养的动物细胞。II. 该转运系统在普通肝细胞中几乎难以察觉，但在肝癌细胞系中活跃。
J Biol Chem. 1982 Apr 25;257(8):4450-7.
2
Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts.阳离子氨基酸转运进入培养的动物细胞。I. 流入培养的人成纤维细胞。
J Biol Chem. 1982 Apr 25;257(8):4443-9.
3
Lysine transport across the small intestine. Stimulating and inhibitory effects of neutral amino acids.赖氨酸在小肠中的转运。中性氨基酸的刺激和抑制作用。
J Membr Biol. 1980 Mar 31;53(1):45-53. doi: 10.1007/BF01871171.
4
A simple and efficient method for reconstitution of amino acid and glucose transport systems from Ehrlich ascites cells.一种从艾氏腹水癌细胞重建氨基酸和葡萄糖转运系统的简单有效方法。
Arch Biochem Biophys. 1984 Jun;231(2):355-65. doi: 10.1016/0003-9861(84)90398-9.
5
Characterization of the polyamine transport system in mouse neuroblastoma cells. Effects of sodium and system A amino acids.小鼠神经母细胞瘤细胞中多胺转运系统的特性。钠和A系统氨基酸的作用。
J Biol Chem. 1984 Apr 25;259(8):4750-6.
6
Recent advances in the biochemistry of polyamines in eukaryotes.真核生物中多胺生物化学的最新进展。
Biochem J. 1986 Mar 1;234(2):249-62. doi: 10.1042/bj2340249.
7
The transport of cationic amino acids across the plasma membrane of mammalian cells.阳离子氨基酸跨哺乳动物细胞膜的转运。
Biochim Biophys Acta. 1985 Dec 9;822(3-4):355-74. doi: 10.1016/0304-4157(85)90015-2.
8
Histamine and serotonin inhibit induction of ornithine decarboxylase by ornithine in perifused Ehrlich ascites tumour cells.组胺和5-羟色胺抑制鸟氨酸对灌流的艾氏腹水癌细胞中鸟氨酸脱羧酶的诱导作用。
FEBS Lett. 1989 Jul 3;250(2):257-61. doi: 10.1016/0014-5793(89)80733-1.
9
Influence of polyamines on membrane functions.多胺对膜功能的影响。
Biochem J. 1989 May 15;260(1):1-10. doi: 10.1042/bj2600001.
10
Altered ornithine metabolism in tumor-bearing mice.
Life Sci. 1989;45(20):1877-84. doi: 10.1016/0024-3205(89)90541-9.