Shiozaki M, Sakai R, Tabuchi M, Eto Y, Kosaka M, Shibai H
Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
Biochem Biophys Res Commun. 1989 Dec 29;165(3):1155-61. doi: 10.1016/0006-291x(89)92723-x.
The in vivo effect of human EDF on erythroid precursors (CFU-E and BFU-E) was investigated in normal and bled mice. In anemic (bled) mice, EDF treatment led to significant dose-dependent rises in the CFU-E and BFU-E levels of bone marrow. An elevation in the level of CFU-E was also seen in the spleen. In normal mice, a significant elevation in the level of bone marrow BFU-E was observed. Thus, EDF has an effect on erythropoiesis in anemic and normal mice in vivo.
在正常小鼠和失血小鼠中研究了人红细胞分化因子（EDF）对红系前体细胞（CFU-E和BFU-E）的体内作用。在贫血（失血）小鼠中，EDF治疗导致骨髓中CFU-E和BFU-E水平呈显著剂量依赖性升高。在脾脏中也观察到CFU-E水平升高。在正常小鼠中，观察到骨髓BFU-E水平显著升高。因此，EDF在体内对贫血小鼠和正常小鼠的红细胞生成均有作用。
