Matsuse T, Ikegami A, Ohga E, Hosoi T, Oka T, Kida K, Fukayama M, Inoue S, Nagase T, Ouchi Y, Fukuchi Y
Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.
Am J Pathol. 1996 Mar;148(3):707-13.
The expression of activin A, one of the transforming growth factor-beta supergene family, was studied in various pulmonary conditions associated with interstitial pulmonary fibrosis (3 cases with diffuse alveolar damage, 6 cases with idiopathic pulmonary fibrosis, and 1 case with pulmonary fibrosis associated with rheumatoid arthritis) using immunohistochemical techniques on paraffin-embedded sections. Controls consisted of 10 cases with normal pulmonary parenchyma, and 2 cases with primary pulmonary hypertension and 1 case with secondary pulmonary hypertension were also studied. The lung specimens from normal parenchyma weakly expressed immunoreactive activin A on the bronchiolar epithelium. In marked contrast, all of the specimens from cases with diffuse alveolar damage and interstitial pulmonary fibrosis demonstrated strong expression of activin A on metaplastic epithelium, hyperplastic smooth muscle cells, desquamated cells, and alveolar macrophages. Pulmonary arteries from patients with primary or secondary pulmonary hypertension showed abundant immunoreactive activin A on smooth muscle cells. These findings suggest a potential role for this growth factor, activin A, in the pathogenesis of pulmonary tissue remodeling associated with interstitial pulmonary fibrosis.
利用免疫组织化学技术，在石蜡包埋切片上研究了转化生长因子-β超基因家族成员之一激活素A在各种与间质性肺纤维化相关的肺部疾病（3例弥漫性肺泡损伤、6例特发性肺纤维化、1例类风湿性关节炎相关的肺纤维化）中的表达情况。对照组包括10例肺实质正常的病例，还研究了2例原发性肺动脉高压病例和1例继发性肺动脉高压病例。正常肺实质的肺标本在细支气管上皮上弱表达免疫反应性激活素A。与之形成显著对比的是，所有弥漫性肺泡损伤和间质性肺纤维化病例的标本在化生上皮、增生的平滑肌细胞、脱落细胞和肺泡巨噬细胞上均显示激活素A的强表达。原发性或继发性肺动脉高压患者的肺动脉在平滑肌细胞上显示丰富的免疫反应性激活素A。这些发现提示这种生长因子激活素A在与间质性肺纤维化相关的肺组织重塑发病机制中可能发挥作用。
