Hendricks W M
Asheboro Dermatology Clinic P.A., NC 27203.
Semin Dermatol. 1991 Dec;10(4):282-92.
Clinical pellagra is a multiple vitamin-deficiency disease. The clinical manifestations include dermatitis, diarrhea, and dementia; the result is often death. Photosensitivity has also been associated with pellagra. Other clinical findings may depend on the nutritional status of the patient. Pellagrins may not have specific cutaneous pathological findings, although necrolytic migratory erythema has been reported in clinical pellagra. Most pellagrins respond to niacin combined with a high-protein diet, although other concomitant vitamin deficiencies may prevent the use of niacin. Clinical pellagra should be considered in the differential diagnosis of patients with chronic alcoholism, malnutrition, and amino acid imbalance.
临床糙皮病是一种多种维生素缺乏疾病。临床表现包括皮炎、腹泻和痴呆；最终结果往往是死亡。光敏性也与糙皮病有关。其他临床发现可能取决于患者的营养状况。糙皮病患者可能没有特定的皮肤病理表现，尽管临床糙皮病中曾有坏死松解性游走性红斑的报道。大多数糙皮病患者对烟酸联合高蛋白饮食有反应，尽管其他伴随的维生素缺乏可能会妨碍烟酸的使用。在对慢性酒精中毒、营养不良和氨基酸失衡患者进行鉴别诊断时应考虑临床糙皮病。
