Morris Martha Clare, Schneider Julie A, Tangney Christine C
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA.
J Alzheimers Dis. 2006 Aug;9(4):429-33. doi: 10.3233/jad-2006-9409.
The B-vitamins, including vitamins B12, B6, B1, B2, niacin (B3) and folate (B9), have been implicated as protective risk factors against cognitive decline and Alzheimer's disease. This commentary reviews the evidence to support protective relations of these vitamins, including consideration of known vitamin deficiency syndromes, theories of underlying biologic mechanisms, and the epidemiologic evidence. We also comment on the potential benefits and harms of vitamin supplementation as well as make recommendations for the direction of future studies.
包括维生素B12、B6、B1、B2、烟酸（B3）和叶酸（B9）在内的B族维生素，已被认为是预防认知能力下降和阿尔茨海默病的保护性风险因素。本评论回顾了支持这些维生素具有保护作用的证据，包括对已知维生素缺乏综合征的考量、潜在生物学机制的理论以及流行病学证据。我们还对维生素补充剂的潜在益处和危害进行了评论，并对未来研究的方向提出了建议。
