关于B族维生素与痴呆症的思考
Thoughts on B-vitamins and dementia.
作者信息
Morris Martha Clare, Schneider Julie A, Tangney Christine C
机构信息
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA.
出版信息
J Alzheimers Dis. 2006 Aug;9(4):429-33. doi: 10.3233/jad-2006-9409.
Abstract
The B-vitamins, including vitamins B12, B6, B1, B2, niacin (B3) and folate (B9), have been implicated as protective risk factors against cognitive decline and Alzheimer's disease. This commentary reviews the evidence to support protective relations of these vitamins, including consideration of known vitamin deficiency syndromes, theories of underlying biologic mechanisms, and the epidemiologic evidence. We also comment on the potential benefits and harms of vitamin supplementation as well as make recommendations for the direction of future studies.
摘要
包括维生素B12、B6、B1、B2、烟酸（B3）和叶酸（B9）在内的B族维生素，已被认为是预防认知能力下降和阿尔茨海默病的保护性风险因素。本评论回顾了支持这些维生素具有保护作用的证据，包括对已知维生素缺乏综合征的考量、潜在生物学机制的理论以及流行病学证据。我们还对维生素补充剂的潜在益处和危害进行了评论，并对未来研究的方向提出了建议。
相似文献
1
Thoughts on B-vitamins and dementia.关于B族维生素与痴呆症的思考
J Alzheimers Dis. 2006 Aug;9(4):429-33. doi: 10.3233/jad-2006-9409.
2
B vitamins and berries and age-related neurodegenerative disorders.B族维生素、浆果与年龄相关性神经退行性疾病
Evid Rep Technol Assess (Full Rep). 2006 Apr(134):1-161.
3
Ask the doctor. Is it true that B vitamins can reduce my risk of Alzheimer's disease and other types of dementia?
Harv Health Lett. 2014 Feb;39(4):2.
4
Folic acid with or without vitamin B12 for cognition and dementia.叶酸联合或不联合维生素B12对认知及痴呆的影响
Cochrane Database Syst Rev. 2003(4):CD004514. doi: 10.1002/14651858.CD004514.
5
B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review.B 族维生素和脂肪酸在预防和治疗老年痴呆症和痴呆症中的作用：系统评价。
J Alzheimers Dis. 2010;22(1):205-24. doi: 10.3233/JAD-2010-090940.
6
The role of B vitamins in preventing and treating cognitive impairment and decline.B 族维生素在预防和治疗认知障碍和衰退中的作用。
Adv Nutr. 2012 Nov 1;3(6):801-12. doi: 10.3945/an.112.002535.
7
Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases.补充维生素B对患有认知相关疾病的老年患者认知功能的疗效。
J Geriatr Psychiatry Neurol. 2017 Jan;30(1):50-59. doi: 10.1177/0891988716673466. Epub 2016 Oct 17.
8
Chapter 30: historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins.第30章：主要神经维生素缺乏症的历史概况：水溶性B族维生素
Handb Clin Neurol. 2010;95:445-76. doi: 10.1016/S0072-9752(08)02130-1.
9
The worldwide challenge of the dementias: a role for B vitamins and homocysteine?痴呆症的全球挑战：B族维生素和同型半胱氨酸起什么作用？
Food Nutr Bull. 2008 Jun;29(2 Suppl):S143-72. doi: 10.1177/15648265080292S119.
10
[Meta-analysis on effect of combined supplementation of folic acid, vitamin B12 and B6 on risk of cardio-cerebrovascular diseases in randomized control trials].[叶酸、维生素B12和B6联合补充对随机对照试验中心脑血管疾病风险影响的Meta分析]
Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Jul;37(7):1028-34. doi: 10.3760/cma.j.issn.0254-6450.2016.07.024.
引用本文的文献
1
Recent advances in electrochemical sensors for vitamin sensing: toward point-of-care micronutrient assessment.用于维生素传感的电化学传感器的最新进展：迈向即时护理微量营养素评估
Discov Nano. 2025 Sep 12;20(1):160. doi: 10.1186/s11671-025-04265-z.
2
Functional benefits of ultra-high hydrostatic pressurized brown rice on cognition, apathy, and bone health in older adults: A 12-month randomized controlled trial.超高静压处理糙米对老年人认知、冷漠及骨骼健康的功能益处：一项为期12个月的随机对照试验。
Exp Ther Med. 2025 Aug 11;30(4):192. doi: 10.3892/etm.2025.12942. eCollection 2025 Oct.
3
Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial.B族维生素在调节同型半胱氨酸及与脑萎缩相关的代谢途径中的作用：来自VITACOG试验的代谢组学见解
Alzheimers Dement. 2025 Jul;21(7):e70521. doi: 10.1002/alz.70521.
4
Correlation Between Dietary Nutrition and Glymphatic System Activity in Healthy Participants.健康受试者饮食营养与类淋巴系统活性之间的相关性
Cureus. 2025 Jan 22;17(1):e77860. doi: 10.7759/cureus.77860. eCollection 2025 Jan.
5
Exploration of the Role of Vitamins in Preventing Neurodegenerative Diseases: Comprehensive Review on Preclinical and Clinical Findings.维生素在预防神经退行性疾病中的作用探索：临床前和临床研究结果的综合综述
Curr Neuropharmacol. 2025;23(5):547-563. doi: 10.2174/011570159X327677240902105443.
6
Comparative brain metabolomics reveals shared and distinct metabolic alterations in Alzheimer's disease and progressive supranuclear palsy.比较脑代谢组学揭示阿尔茨海默病和进行性核上性麻痹中共同和独特的代谢改变。
Alzheimers Dement. 2024 Dec;20(12):8294-8307. doi: 10.1002/alz.14249. Epub 2024 Oct 22.
7
Nutrition, Exercise, and Cognitive Rehabilitation for Dementia Prevention.用于预防痴呆症的营养、运动和认知康复
Juntendo Iji Zasshi. 2024 Feb 16;70(1):9-22. doi: 10.14789/jmj.JMJ23-0032-R. eCollection 2024.
8
Optimization of Cyanocobalamin (Vitamin B) Sorption onto Mesoporous Superparamagnetic Iron Oxide Nanoparticles.优化氰钴胺素（维生素 B）在介孔超顺磁性氧化铁纳米粒子上的吸附。
Molecules. 2024 May 1;29(9):2094. doi: 10.3390/molecules29092094.
9
Vitamin B: a scoping review for Nordic Nutrition Recommendations 2023.维生素B：2023年北欧营养建议的范围审查
Food Nutr Res. 2023 Dec 19;67. doi: 10.29219/fnr.v67.10259. eCollection 2023.
10
Association of Anemia with Cognitive Function and Dementia Among Older Adults: The Role of Inflammation.贫血与老年人认知功能和痴呆的关系：炎症的作用。
J Alzheimers Dis. 2023;96(1):125-134. doi: 10.3233/JAD-230483.
本文引用的文献
1
Reduced risk of Alzheimer's disease with high folate intake: the Baltimore Longitudinal Study of Aging.高叶酸摄入量可降低患阿尔茨海默病的风险：巴尔的摩衰老纵向研究
Alzheimers Dement. 2005 Jul;1(1):11-8. doi: 10.1016/j.jalz.2005.06.001.
2
Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease.膳食叶酸、维生素B-12和B-6与阿尔茨海默病的发病无关。
J Alzheimers Dis. 2006 Aug;9(4):435-43. doi: 10.3233/jad-2006-9410.
3
Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study.同型半胱氨酸、维生素B-12、叶酸与老年人认知功能减退风险：莱顿85岁及以上人群研究
Am J Clin Nutr. 2005 Oct;82(4):866-71. doi: 10.1093/ajcn/82.4.866.
4
Homocysteine and folate as risk factors for dementia and Alzheimer disease.同型半胱氨酸和叶酸作为痴呆症和阿尔茨海默病的风险因素。
Am J Clin Nutr. 2005 Sep;82(3):636-43. doi: 10.1093/ajcn.82.3.636.
5
High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study.高同型半胱氨酸和低B族维生素预示老年男性认知能力下降：退伍军人事务部规范老化研究
Am J Clin Nutr. 2005 Sep;82(3):627-35. doi: 10.1093/ajcn.82.3.627.
6
When is baseline adjustment useful in analyses of change? An example with education and cognitive change.在变化分析中，基线调整何时有用？以教育与认知变化为例。
Am J Epidemiol. 2005 Aug 1;162(3):267-78. doi: 10.1093/aje/kwi187. Epub 2005 Jun 29.
7
Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons.社区居住老年人的膳食叶酸和维生素B12摄入量与认知功能衰退
Arch Neurol. 2005 Apr;62(4):641-5. doi: 10.1001/archneur.62.4.641.
8
The association between lifestyle-related factors and plasma homocysteine levels in healthy individuals from the "ATTICA" Study.“阿提卡”研究中健康个体的生活方式相关因素与血浆同型半胱氨酸水平之间的关联。
Int J Cardiol. 2005 Feb 28;98(3):471-7. doi: 10.1016/j.ijcard.2003.12.036.
9
Increases in homocysteine are related to worsening of stroop scores in healthy elderly persons: a prospective follow-up study.同型半胱氨酸水平升高与健康老年人Stroop测验得分变差有关：一项前瞻性随访研究。
J Gerontol A Biol Sci Med Sci. 2004 Dec;59(12):1323-7. doi: 10.1093/gerona/59.12.1323.
10
Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging.同型半胱氨酸与维生素叶酸、维生素B6和维生素B12作为老年高功能成年人认知功能及衰退预测指标的研究：麦克阿瑟成功老龄化研究
Am J Med. 2005 Feb;118(2):161-7. doi: 10.1016/j.amjmed.2004.08.019.
Zotero 插件