Washington State University, Abelson 435, P.O. Box 66224, Pullman, WA, USA.
Molecules. 2010 Jan 20;15(1):442-59. doi: 10.3390/molecules15010442.
Vitamin B6 is an intriguing molecule that is involved in a wide range of metabolic, physiological and developmental processes. Based on its water solubility and high reactivity when phosphorylated, it is a suitable co-factor for many biochemical processes. Furthermore the vitamin is a potent antioxidant, rivaling carotenoids or tocopherols in its ability to quench reactive oxygen species. It is therefore not surprising that the vitamin is essential and unquestionably important for the cellular metabolism and well-being of all living organisms. The review briefly summarizes the biosynthetic pathways of vitamin B6 in pro- and eukaryotes and its diverse roles in enzymatic reactions. Finally, because in recent years the vitamin has often been considered beneficial for human health, the review will also sum up and critically reflect on current knowledge how human health can profit from vitamin B6.
维生素 B6 是一种有趣的分子，它参与了广泛的代谢、生理和发育过程。基于其水溶性和磷酸化时的高反应性，它是许多生化过程的合适辅酶。此外，维生素是一种有效的抗氧化剂，其清除活性氧的能力可与类胡萝卜素或生育酚相媲美。因此，毫不奇怪，维生素对所有生物体的细胞代谢和健康都是必不可少的，也是非常重要的。本文简要总结了维生素 B6 在原核生物和真核生物中的生物合成途径及其在酶反应中的多种作用。最后，由于近年来维生素常被认为对人类健康有益，本文还将总结和批判性地反映当前的知识，即人类健康如何受益于维生素 B6。
