Ribeiro-Silva Alfredo
Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Diagn Pathol. 2007 Jul 23;2:26. doi: 10.1186/1746-1596-2-26.
An 84-year-old woman underwent hysterectomy due to a friable endometrial mass infiltrating almost half way through the myometrial wall. The tumor consisted of papillary structures with thin fibrovascular cores covered by several layers of pleomorphic cells. The deeply located neoplastic cells were ovoid with a pale eosinophilic cytoplasm resembling urothelial cells. A diagnosis of papillary squamous cell carcinoma of the endometrium with transitional cell differentiation was made. Although she recovered well after surgery, she died one year later because of disseminated disease. In an attempt to obtain new insights into the physiopathology of this very rare tumor, an immunohistochemical panel with 32 markers was performed. The neoplastic cells were positive for cytokeratin 5, vimentin, p63, p21, VEGF, Ki67, BAG1, and bcl-2. The expression of BAG-1 and bcl-2 may suggest that anti-apoptotic stimuli are preponderant in this neoplasm.
一名84岁女性因子宫内膜肿物质地脆且浸润至肌层近一半深度而接受了子宫切除术。肿瘤由具有薄纤维血管轴心的乳头状结构组成，被多层多形性细胞覆盖。深部的肿瘤细胞呈卵圆形，胞质淡嗜酸性，类似尿路上皮细胞。诊断为具有移行细胞分化的子宫内膜乳头状鳞状细胞癌。尽管她术后恢复良好，但一年后因疾病播散而死亡。为了对这种极为罕见的肿瘤的生理病理学获得新的见解，进行了包含32种标志物的免疫组织化学检测。肿瘤细胞细胞角蛋白5、波形蛋白、p63、p21、血管内皮生长因子（VEGF）、Ki67、BAG1和bcl-2呈阳性。BAG-1和bcl-2的表达可能表明抗凋亡刺激在该肿瘤中占优势。
