Jafar T H, Qadri Z, Chaturvedi N
Clinical Epidemiology Unit, Department of Community Health Sciences and Medicine, Aga Khan University, Stadium Road, Karachi, Pakistan.
Heart. 2008 Apr;94(4):408-13. doi: 10.1136/hrt.2007.120774. Epub 2007 Jul 23.
Indo-Pakistani populations have one of the highest risks of coronary artery disease (CAD) in the world. A population-based, cross-sectional survey was conducted on 3143 adults aged >or=40 years from 12 randomly selected communities in Karachi, Pakistan. Apart from smoking, women had more CAD risk factors (diabetes, hypertension, obesity, dyslipidaemia) than men. Definite CAD (history and Q waves on ECG) was more prevalent in men than in women (6.1% vs 4.0%; p = 0.009). In contrast, ischaemic and major ECG changes were twice as prevalent in women as in men (29.4% vs 15.6%, and 21.0% vs 10.5%; p<0.001 for each, respectively). All measures of CAD were strongly predicted by the metabolic syndrome, but that failed to account for the greater prevalence of ECG abnormalities in women than in men. The findings indicate that one in five middle-aged adults in urban Pakistan may have underlying CAD. Women are at greater risk than men.
NCT00327574.
印巴人群是世界上患冠状动脉疾病（CAD）风险最高的人群之一。在巴基斯坦卡拉奇随机选取的12个社区中，对3143名年龄≥40岁的成年人进行了一项基于人群的横断面调查。除吸烟外，女性比男性有更多的CAD危险因素（糖尿病、高血压、肥胖、血脂异常）。确诊的CAD（病史和心电图Q波）在男性中比在女性中更普遍（6.1%对4.0%；p = 0.009）。相比之下，缺血性和主要心电图变化在女性中的患病率是男性的两倍（29.4%对15.6%，以及21.0%对10.5%；每项p均<0.001）。代谢综合征能强烈预测所有CAD指标，但这无法解释女性心电图异常患病率高于男性的现象。研究结果表明，巴基斯坦城市中五分之一的中年成年人可能患有潜在的CAD。女性比男性面临的风险更大。
NCT00327574。
