Hareendran Asha, Doll Helen, Wild Diane J, Moffatt Christine J, Musgrove Elaine, Wheatley Carolyn, Franks Peter J
Outcomes Research, Pfizer Ltd, Sandwich, Kent, UK.
Wound Repair Regen. 2007 Jul-Aug;15(4):465-73. doi: 10.1111/j.1524-475X.2007.00253.x.
To develop and validate a disease-specific quality of life (QoL) measure, based on the conceptual model of the SKINDEX-29 for patients with a chronic venous leg ulcer (VLU), in-depth interviews, and focus groups of patients (n=36) with VLU were used to generate VLU-specific items. These items were added to selected SKINDEX-29 items that were adapted for use in VLU. Further samples of VLU patients were used for item reduction (n=124) and to assess the psychometric properties of the new tool (n=120). The final VLU-QoL contained 34 items: 17 items adapted from the SKINDEX-29 and 17 VLU-specific items. Factor analysis of the items confirmed the existence of three hypothesized domains: Activities (12 items), Psychological (12 items), and Symptom Distress (10 items). Reliability in terms of internal consistency and test-retest reliability was found to be good. The measure was also found to be valid and responsive to clinical change. The VLU-QoL has good psychometric properties. The instrument's sensitivity to differences in clinical outcome and responsiveness to change in clinical parameters makes it a useful tool to assess the outcomes of treatment from the patients' perspective.
为了开发并验证一种基于SKINDEX - 29概念模型的慢性下肢静脉溃疡（VLU）患者特定疾病生活质量（QoL）测量工具，通过对36名VLU患者进行深入访谈和焦点小组讨论来生成VLU特定项目。这些项目被添加到经过调整以适用于VLU的选定SKINDEX - 29项目中。进一步选取VLU患者样本进行项目精简（n = 124）并评估新工具的心理测量特性（n = 120）。最终的VLU - QoL包含34个项目：17个改编自SKINDEX - 29的项目和17个VLU特定项目。对这些项目的因子分析证实了存在三个假设领域：活动（12个项目）、心理（12个项目）和症状困扰（10个项目）。在内部一致性和重测信度方面的信度良好。该测量工具还被发现具有有效性且对临床变化有反应性。VLU - QoL具有良好的心理测量特性。该工具对临床结果差异的敏感性以及对临床参数变化的反应性使其成为从患者角度评估治疗结果的有用工具。
