Metzmacher Iris, Ruth Peter, Abel Martin, Friess Wolfgang
Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Munich, Germany.
Wound Repair Regen. 2007 Jul-Aug;15(4):549-55. doi: 10.1111/j.1524-475X.2007.00263.x.
Chronic wounds are characterized by failure in wound-healing response and a delay in healing or nonclosure of the wounds. This results in a high effort in clinical treatment and/or home care. A major difference between acute wounds and chronic wounds is the imbalance of proteinase inhibitors and proteinase activity that regulates the degradation and regeneration of the extracellular matrix proteins. Collagen and collagen/oxidized regenerated cellulose dressings act as a competitive substrate for matrix metalloproteinase-2, matrix metalloproteinase-9, and bacterial collagenase and influence this imbalance positively. Both wound dressings, approved for chronic wound treatment, the bovine collagen type I sponge and the oxidized regenerated cellulose collagen sponge, did not differ significantly in their sorption profiles for all enzymes. In general, binding was enhanced with a longer incubation time. The density of the device and the accessible surface, which can be controlled by the manufacturing process, are the crucial factors for the efficiency of the wound dressing.
慢性伤口的特征在于伤口愈合反应失败以及伤口愈合延迟或无法闭合。这导致临床治疗和/或家庭护理的工作量很大。急性伤口和慢性伤口之间的一个主要区别在于蛋白酶抑制剂与调节细胞外基质蛋白降解和再生的蛋白酶活性之间的失衡。胶原蛋白和胶原蛋白/氧化再生纤维素敷料作为基质金属蛋白酶-2、基质金属蛋白酶-9和细菌胶原酶的竞争性底物，对这种失衡有积极影响。两种被批准用于慢性伤口治疗的伤口敷料，即I型牛胶原蛋白海绵和氧化再生纤维素胶原蛋白海绵，对所有酶的吸附情况没有显著差异。一般来说，孵育时间越长，结合力越强。敷料的密度和可接触表面（可通过制造工艺控制）是影响伤口敷料效率的关键因素。
