Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
BerlinAnalytix GmbH, Berlin, Germany.
In Vivo. 2021 Sep-Oct;35(5):2541-2549. doi: 10.21873/invivo.12536.
BACKGROUND/AIM: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications.
After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established soft and hard tissue materials cerabone and Jason membrane (both botiss biomaterials GmbH, Zossen, Germany).
Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm In vitro, all foams showed sufficient cytocompatibility.
Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.
背景/目的：本研究的目的是开发一种新型医用胶原泡沫，用于构思、生产、材料分析和细胞相容性分析。
从牛源中创新地生产出各种胶原海绵后，根据 EN ISO 10993-5/-12 对其体外结构（包括孔径）和体外细胞相容性进行分析。在体外，将胶原泡沫与已建立的软、硬组织材料 Cerabone 和 Jason 膜（均为 botiss biomaterials GmbH，Zossen，德国）进行比较。
成功地从牛源中生产出具有不同成分的胶原泡沫。在体实验中，泡沫具有稳定且持久的初级结构质量，泡孔面积为 1000 至 2000μm。体外实验中，所有泡沫均显示出足够的细胞相容性。
胶原海绵是一种有前途的硬组织和软组织再生材料。未来的研究可以集中在泡沫中整合和研究不同的添加剂。
