Kuppusamy U R, Das N P
Department of Biochemistry, Faculty of Medicine, National University of Singapore.
Experientia. 1991 Dec 1;47(11-12):1196-200. doi: 10.1007/BF01918384.
In vitro studies showed that the flavonoid aglycones apigenin, luteolin and kaempferol inhibited the hyaluronidase activity of five different venoms dose-dependently. They were also able to delay the venom action when injected into mice. Naringenin, catechin and flavonoid glycosides had no effect. The flavonoids with unsubstituted hydroxyl groups at C-positions 5, 7 and 4', a double bond between carbons 2 and 3, as well as a ketone group at position 4, exhibited potent inhibitory actions on the venom hyaluronidases.
体外研究表明，黄酮苷元芹菜素、木犀草素和山奈酚可剂量依赖性地抑制五种不同毒液的透明质酸酶活性。当将它们注射到小鼠体内时，还能够延缓毒液的作用。柚皮素、儿茶素和黄酮苷则没有效果。在C-5、C-7和C-4'位具有未取代羟基、碳-2和碳-3之间有双键以及在C-4位有酮基的黄酮类化合物，对毒液透明质酸酶表现出强大的抑制作用。
