肝素后肝脂酶活性的变异性与非裔美国人的血浆脂联素水平相关。

Variability in postheparin hepatic lipase activity is associated with plasma adiponectin levels in African Americans.

作者信息

Clarenbach Jacob J, Vega Gloria Lena, Adams-Huet Beverley, Considine Robert V, Ricks Madia, Sumner Anne E

机构信息

Center for Human Nutrition, Donald W. Reynolds Cardiovascular Clinical Research Center of the University of Texas Southwestern Medical Center and Metabolic Unit, Veterans Affairs Medical Center, Dallas, TX, USA.

出版信息

J Investig Med. 2007 May;55(4):187-94. doi: 10.2310/6650.2007.07001.

DOI:10.2310/6650.2007.07001

PMID:17651673

Abstract

BACKGROUND

African Americans commonly have normal high-density lipoprotein cholesterol (HDL-C) and low triglyceride levels despite having insulin resistance and obesity. The higher than expected HDL-C levels are usually attributed to low levels of hepatic triglyceride lipase (HTGL) activity. Factors that regulate HTGL in African Americans are not well delineated.

METHODS

In the current study, HTGL activity was examined in relation to indices of body fat (body mass index [BMI] and waist circumference [WC]), insulin resistance (fasting plasma insulin and homeostasis model assessment of insulin resistance [HOMA-IR] index), and adipokines (adiponectin and leptin). Sixty-three African Americans (33 men, 30 women; median age 31 years, range 20-50 years; median BMI 28.6 kg/m2, range 19.7-54.7 kg/m2) had anthropometry and measurement of postheparin lipase activities (HTGL), plasma HDL-C, triglycerides, and plasma adiponectin.

RESULTS

HTGL correlated strongly with HDL-C (r = -.52, p < .0001) and adiponectin (r = -.49, p < .001). HTGL increased with BMI and WC (r = .297, p = .018 and r = .301, p = .016, respectively). Adiponectin correlated strongly with HDL-C (r = .50, p < .0001) and triglycerides (r = -.493, p < .001). From multiple regression models, 28% of HTGL variability among African Americans can be explained by adiponectin levels in combination with gender and 35% of HTGL is explained with HDL-C included in the model.

CONCLUSION

The data suggest that adiponectin is a significant metabolic concomitant of HTGL activity in African Americans.

摘要

背景

非裔美国人尽管存在胰岛素抵抗和肥胖，但通常具有正常的高密度脂蛋白胆固醇（HDL-C）水平和低甘油三酯水平。高于预期的HDL-C水平通常归因于肝甘油三酯脂肪酶（HTGL）活性水平较低。调节非裔美国人HTGL的因素尚未明确。

方法

在本研究中，研究了HTGL活性与体脂指标（体重指数[BMI]和腰围[WC]）、胰岛素抵抗（空腹血浆胰岛素和胰岛素抵抗稳态模型评估[HOMA-IR]指数）以及脂肪因子（脂联素和瘦素）之间的关系。63名非裔美国人（33名男性，30名女性；年龄中位数31岁，范围20 - 50岁；BMI中位数28.6 kg/m²，范围19.7 - 54.7 kg/m²）进行了人体测量，并测量了肝素后脂肪酶活性（HTGL）、血浆HDL-C、甘油三酯和血浆脂联素。

结果

HTGL与HDL-C（r = -0.52，p < 0.0001）和脂联素（r = -0.49，p < 0.001）密切相关。HTGL随BMI和WC升高（分别为r = 0.297，p = 0.018和r = 0.301，p = 0.016）。脂联素与HDL-C（r = 0.50，p < 0.0001）和甘油三酯（r = -0.493，p < 0.001）密切相关。在多元回归模型中，非裔美国人中HTGL变异性的28%可由脂联素水平与性别共同解释，模型中纳入HDL-C后可解释35%的HTGL变异性。