Vega Gloria Lena, Grundy Scott M
Center for Human Nutrition and Departments of Clinical Nutrition, Internal Medicine and The Metabolic Unit of the Veterans Administration North Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USA.
J Obes. 2013;2013:409679. doi: 10.1155/2013/409679. Epub 2013 Mar 6.
High adiponectin/leptin ratio may be protective from metabolic risks imparted by high triglyceride, low HDL, and insulin resistance.
This cross-sectional study examines plasma adipokine levels in 428 adult men who were subgrouped according to low (<6.5 μ g/mL)and high (≥6.5 μ g/mL)adiponectin levels or a low or high ratio of adiponectin/leptin.
Men with high adiponectin/leptin ratio had lower plasma triglyceride and higher HDL cholesterol than those with low ratio. Similarly, those with high adiponectin/leptin ratio had lower TG/HDL cholesterol ratio and HOMA2-IR than those with low ratio. In contrast, levels of adiponectin or the ratio of adiponectin/leptin did not associate with systolic blood pressure. But the ratio of adiponectin/leptin decreased progressively with the increase in the number of risk factors for metabolic syndrome.
Adipokine levels may reflect adipose tissue triglyceride storage capacity and insulin sensitivity. Leptin is an index of fat mass, and adiponectin is a biomarker of triglyceride metabolism and insulin sensitivity. Men with high adiponectin/leptin ratios have better triglyceride profile and insulin sensitivity than men with a low ratio regardless of waist girth.
高脂联素/瘦素比值可能对高甘油三酯、低高密度脂蛋白及胰岛素抵抗所带来的代谢风险具有保护作用。
这项横断面研究检测了428名成年男性的血浆脂肪因子水平，这些男性根据脂联素水平低（<6.5μg/mL）和高（≥6.5μg/mL）或脂联素/瘦素比值低或高进行亚组划分。
脂联素/瘦素比值高的男性比比值低的男性血浆甘油三酯水平更低，高密度脂蛋白胆固醇水平更高。同样，脂联素/瘦素比值高的男性甘油三酯/高密度脂蛋白胆固醇比值和HOMA2-IR比比值低的男性更低。相比之下，脂联素水平或脂联素/瘦素比值与收缩压无关。但脂联素/瘦素比值随着代谢综合征风险因素数量的增加而逐渐降低。
脂肪因子水平可能反映脂肪组织甘油三酯储存能力和胰岛素敏感性。瘦素是脂肪量的指标，脂联素是甘油三酯代谢和胰岛素敏感性的生物标志物。无论腰围如何，脂联素/瘦素比值高的男性比比值低的男性具有更好的甘油三酯水平和胰岛素敏感性。
