Miller Gretchen M, Stripp Richard
Department of Science, John Jay College of Criminal Justice, 445 West 59th Street, NY, NY 10019, USA.
Leg Med (Tokyo). 2007 Sep;9(5):258-64. doi: 10.1016/j.legalmed.2007.04.001.
In America, recent growth in the popularity of Chinese herbal/patent medicines (CHM/CPM) has generated concerns as to the safety of these and other herbal remedies. Lack of strict federal regulations has lead to the possibility of improper labeling and even adulteration of these products with western drugs or other chemical contaminants. Our laboratory has conducted an analytical study to determine the presence of undeclared pharmaceuticals and therapeutic substances within CHM/CPM sold in New York City's Chinatown. Ninety representative samples randomly purchased in the form of pills, tablets, creams and teas were screened by appropriate analytical techniques including TLC, GC/MS and HPLC. Five samples contained nine different western pharmaceuticals. Two of these samples contained undeclared or mislabeled substances. One sample contained two pharmaceuticals contraindicated in people for whom the product was intended. Drugs identified include promethazine, chlormethiazole, chlorpheniramine, diclofenac, chlordiazepoxide, hydrochlorothiazide, triamterene, diphenhydramine and sildenafil citrate (Viagra).
在美国,近年来中药/中成药(CHM/CPM)的受欢迎程度不断上升,这引发了人们对这些及其他草药疗法安全性的担忧。由于缺乏严格的联邦法规,这些产品可能存在标签不当的问题,甚至可能被西药或其他化学污染物掺假。我们实验室进行了一项分析研究,以确定在纽约市唐人街销售的CHM/CPM中是否存在未申报的药物和治疗物质。通过薄层色谱法(TLC)、气相色谱/质谱联用仪(GC/MS)和高效液相色谱法(HPLC)等适当的分析技术,对以药丸、片剂、乳膏和茶剂形式随机购买的90个代表性样品进行了筛选。5个样品含有9种不同的西药。其中2个样品含有未申报或标签错误的物质。有一个样品含有两种该产品适用人群禁用的药物。鉴定出的药物包括异丙嗪、氯美噻唑、氯苯那敏、双氯芬酸、氯氮卓、氢氯噻嗪、氨苯蝶啶、苯海拉明和枸橼酸西地那非(伟哥)。