Nwanodi Oroma, Choi Christine, Khulpateea Neekianund
Women's Health Department, Myrtle Hilliard Davis Comprehensive Health Centers, 5471 Dr. Martin Luther King Drive, Saint Louis, MO, 63112, USA.
Arch Gynecol Obstet. 2008 Feb;277(2):171-4. doi: 10.1007/s00404-007-0428-z. Epub 2007 Jul 25.
The characteristics of women presenting with asymptomatic ovarian or peritoneal cancer diagnosed following evaluation for abnormal cervicovaginal cytology are currently undefined.
We present a case of a 51-year-old woman with asymptomatic stage IIIC ovarian cancer whose diagnosis was triggered by evaluation for adenocarcinoma and atypical glandular cells of undetermined significance (AGUS) on cervical cytology. We also present a case of a 53-year-old woman with AGUS cervical cytology on two occasions, found to have stage III peritoneal cancer at exploratory laparotomy.
We conducted a systematic search for articles to enable a review of asymptomatic cases of ovarian and peritoneal cancer, which presented via abnormal cervicovaginal cytology. The mean age at presentation with peritoneal cancer was 47.8 years old, which is similar to that of ovarian cancer of 50.5 years. Staging was provided in 13 cases, 11 of which (85%) were at least stage IIIA or greater. In terms of age greater than 50 years old, cervicovaginal cytology interpreted as AGUS, having a negative initial work-up, and advanced disease stage at presentation, the two cases presented are consistent with the literature. Abnormal cervicovaginal cytology as a presenting diagnostic criterion of cancer of the ovary or peritoneum is often representative of advanced disease.
目前，对于因宫颈阴道细胞学异常而接受评估后被诊断出的无症状卵巢癌或腹膜癌女性患者的特征尚不明确。
我们报告一例51岁无症状IIIC期卵巢癌女性患者，其诊断是由宫颈细胞学检查发现腺癌及意义不明确的非典型腺细胞（AGUS）引发的。我们还报告一例53岁女性患者，其宫颈细胞学检查两次出现AGUS，在剖腹探查术中发现患有III期腹膜癌。
我们系统检索了相关文章，以便对通过宫颈阴道细胞学异常表现出的无症状卵巢癌和腹膜癌病例进行综述。腹膜癌患者的平均发病年龄为47.8岁，与卵巢癌的50.5岁相似。13例患者提供了分期信息，其中11例（85%）至少为IIIA期或更高分期。就年龄大于50岁、宫颈阴道细胞学检查结果为AGUS、初始检查结果为阴性且发病时疾病分期较晚而言，所报告的这两例病例与文献一致。宫颈阴道细胞学异常作为卵巢或腹膜癌的诊断标准往往代表疾病处于晚期。
