Sosnovik David E, Dai Guangping, Nahrendorf Matthias, Rosen Bruce R, Seethamraju Ravi
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
J Magn Reson Imaging. 2007 Aug;26(2):279-87. doi: 10.1002/jmri.20966.
To evaluate the use of a transmit-receive surface (TRS) coil and a cardiac-tailored intensity-correction algorithm for cardiac MRI in mice at 9.4 Tesla (9.4T).
Fast low-angle shot (FLASH) cines, with and without delays alternating with nutations for tailored excitation (DANTE) tagging, were acquired in 13 mice. An intensity-correction algorithm was developed to compensate for the sensitivity profile of the surface coil, and was tailored to account for the unique distribution of noise and flow artifacts in cardiac MR images.
Image quality was extremely high and allowed fine structures such as trabeculations, valve cusps, and coronary arteries to be clearly visualized. The tag lines created with the surface coil were also sharp and clearly visible. Application of the intensity-correction algorithm improved signal intensity, tissue contrast, and image quality even further. Importantly, the cardiac-tailored properties of the correction algorithm prevented noise and flow artifacts from being significantly amplified.
The feasibility and value of cardiac MRI in mice with a TRS coil has been demonstrated. In addition, a cardiac-tailored intensity-correction algorithm has been developed and shown to improve image quality even further. The use of these techniques could produce significant potential benefits over a broad range of scanners, coil configurations, and field strengths.
评估发射-接收表面（TRS）线圈及心脏定制的强度校正算法在9.4特斯拉（9.4T）小鼠心脏磁共振成像（MRI）中的应用。
对13只小鼠进行了快速低角度激发（FLASH）电影成像，包括有无延迟交替与间断性绝热脉冲用于定制激发（DANTE）标记。开发了一种强度校正算法以补偿表面线圈的灵敏度分布，并针对心脏MR图像中噪声和血流伪影的独特分布进行定制。
图像质量极高，能够清晰显示诸如小梁、瓣膜尖和冠状动脉等精细结构。使用表面线圈创建的标记线也清晰锐利、可见。强度校正算法的应用进一步提高了信号强度、组织对比度和图像质量。重要的是，校正算法的心脏定制特性可防止噪声和血流伪影被显著放大。
已证明使用TRS线圈对小鼠进行心脏MRI的可行性和价值。此外，已开发出一种心脏定制的强度校正算法，其可进一步提高图像质量。这些技术的应用可能会在广泛的扫描仪、线圈配置和场强范围内产生显著的潜在益处。
