Institute of Radiology, University of Würzburg, Würzburg, Germany.
J Magn Reson Imaging. 2011 Nov;34(5):1072-9. doi: 10.1002/jmri.22718. Epub 2011 Sep 19.
To combine global cardiac function imaging with compressed sensing (CS) in order to reduce scan time and to validate this technique in normal mouse hearts and in a murine model of chronic myocardial infarction.
To determine the maximally achievable acceleration factor, fully acquired cine data, obtained in sham and chronically infarcted (MI) mouse hearts were 2-4-fold undersampled retrospectively, followed by CS reconstruction and blinded image segmentation. Subsequently, dedicated CS sampling schemes were implemented at a preclinical 9.4 T magnetic resonance imaging (MRI) system, and 2- and 3-fold undersampled cine data were acquired in normal mouse hearts with high temporal and spatial resolution.
The retrospective analysis demonstrated that an undersampling factor of three is feasible without impairing accuracy of cardiac functional parameters. Dedicated CS sampling schemes applied prospectively to normal mouse hearts yielded comparable left-ventricular functional parameters, and intra- and interobserver variability between fully and 3-fold undersampled data.
This study introduces and validates an alternative means to speed up experimental cine-MRI without the need for expensive hardware.
将心脏功能整体成像与压缩感知（CS）相结合，以缩短扫描时间，并在正常小鼠心脏和慢性心肌梗死小鼠模型中验证该技术。
为确定最大可实现的加速因子，对假手术和慢性梗死（MI）小鼠心脏的全采集电影数据进行了 2-4 倍的回顾性欠采样，随后进行 CS 重建和盲法图像分割。随后，在临床前 9.4 T 磁共振成像（MRI）系统上实施了专用 CS 采样方案，并在具有高时间和空间分辨率的正常小鼠心脏中采集了 2 倍和 3 倍欠采样的电影数据。
回顾性分析表明，在不影响心脏功能参数准确性的情况下，三分之一的欠采样因子是可行的。前瞻性应用于正常小鼠心脏的专用 CS 采样方案得出了可比的左心室功能参数，以及完全和 3 倍欠采样数据之间的观察者内和观察者间的可变性。
本研究介绍并验证了一种替代方法，可在不使用昂贵硬件的情况下加速实验性电影-MRI。
