Wang Dong-Chun, Tan Ai-Min, Ma Shi-Pin, Liu Kang
Jiangsu Simcere Pharmaceutical Research Company Ltd, Nanjing 210042, China.
Zhongguo Zhong Yao Za Zhi. 2007 May;32(10):965-8, 997.
To study the curative effects of Xianling Qianggu koufuye (XLQG) on postmenopausal osteoporosis in ovariectomized female rats.
Sixty female Sprague-dawley rats aged 12-months were used, 50 of them were ovariectomized and randomly divided into 5 groups: ovariectomized (OVX), OVX + Nylestriol, OVX + XLQG (high dose, middle dose, low dose), and the others were sham-operated group. Rats were treated with drugs starting at the 45 day after the operation for 90 days. Double in vivo fluorochrome labeling was administered to all rats. At the end-point of study, the blood was collected to detecte the contents of ALP and StrACP in serum, and the fourth lumar vertebra (LV4) and femur bone sections were cut and stained for bone histomorphometric analyses, biomechanical analyses and BMP analyses.
XLQGKFY decreased greatly the StrACP content, increased BMP and bone stiffness, and improved the bone biomechanical property.
Xianling Qianggu koufuye has a curative effect on postmenopausal osteoporosis, which provides for clinical use.
研究仙灵强骨口服液（XLQG）对去卵巢雌性大鼠绝经后骨质疏松症的疗效。
选用60只12月龄雌性Sprague-dawley大鼠，其中50只去卵巢并随机分为5组：去卵巢组（OVX）、去卵巢+尼尔雌醇组、去卵巢+XLQG高剂量组、去卵巢+XLQG中剂量组、去卵巢+XLQG低剂量组，其余为假手术组。术后45天开始给药，持续90天。对所有大鼠进行双荧光素体内标记。在研究终点，采集血液检测血清中碱性磷酸酶（ALP）和抗酒石酸酸性磷酸酶（StrACP）的含量，并切取第四腰椎（LV4）和股骨骨切片进行骨组织形态计量学分析、生物力学分析和骨形态发生蛋白（BMP）分析。
仙灵强骨口服液高剂量组能显著降低StrACP含量，增加BMP和骨硬度，改善骨生物力学性能。
仙灵强骨口服液对绝经后骨质疏松症有治疗作用，为临床应用提供了依据。
