Wadsten-Hindrichsen Pia, Bender Johanna, Unga Johan, Engström Sven
Pharmaceutical Technology, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden.
J Colloid Interface Sci. 2007 Nov 15;315(2):701-13. doi: 10.1016/j.jcis.2007.07.011. Epub 2007 Jul 10.
The aqueous phase behavior of phytantriol (PT) in mixtures of monoolein (MO), distearoylphosphatidylglycerol (DSPG), propylene glycol (PG), polyethylene glycol 400 (PEG 400) and 2-methyl-2,4-pentanediol (MPD) was investigated by visual inspection, polarized light microscopy and small angle X-ray diffraction at room temperature. The phase diagrams of PT and MO in water are qualitatively very similar and PT/MO mixtures in excess water form one cubic phase of space group Pn3m irrespective of mixing ratio. The addition of the charged membrane lipid DSPG to the PT system gives rise to a considerable water swelling of the cubic phases as well as the occurrence of a cubic phase of space group Im3m. Whereas all three solvents studied give rise to a sponge (L3) phase in the MO-water system, this phase was only found when MPD was added to the PT-water system. The results are discussed with respect to the chemical differences between PT and MO.
通过目视检查、偏光显微镜和小角X射线衍射，在室温下研究了植烷三醇（PT）在单油酸甘油酯（MO）、二硬脂酰磷脂酰甘油（DSPG）、丙二醇（PG）、聚乙二醇400（PEG 400）和2-甲基-2,4-戊二醇（MPD）混合物中的水相行为。PT和MO在水中的相图在定性上非常相似，并且过量水中的PT/MO混合物无论混合比例如何都会形成空间群为Pn3m的一个立方相。向PT体系中添加带电荷的膜脂DSPG会导致立方相出现相当大的水溶胀，以及出现空间群为Im3m的立方相。虽然所研究的所有三种溶剂在MO-水体系中都会产生海绵状（L3）相，但只有当MPD添加到PT-水体系中时才会发现该相。针对PT和MO之间的化学差异对结果进行了讨论。
