Gandolfo S, Carrozzo M, Carbone M, Broccoletti R, Cascio G
Department of Oral Medicine and Periodontology, School of Medicine and Dentistry, University of Turin.
Bull Group Int Rech Sci Stomatol Odontol. 1994 Sep-Dec;37(3-4):71-7.
Serum humoral immunological parameters were determined in 25 patients with atrophic-erosive forms of oral lichen planus (OLP) (Group 1), in 28 patients with reticular-plaque-like lesions of OLP (Group 2) and in 21 healthy patients without oral lesions (Group 3). Comparing patients affected by atrophic-erosive forms of OLP (Group 1) with normal controls (Group 3), increased levels of serum IgG approaching the statistical significance were found (Kruskal-Wallis test p = 0.0572). It was also found a significantly higher value of kappa (Kruskal-Wallis test p = 0.0017; Mann-Whitney test with Bonferroni's correction p < 0.001) and lambda (Kruskal-Wallis test p = 0.0346; Mann-Whitney test with Bonferroni's correction p = 0.013) light chains in patients with atrophic-erosive OLP (Group 1) as compared with normal controls (Group 3). However these higher levels were probably caused by strong prevalence of chronic liver diseases (40%), in patients with atrophic-erosive variety of OLP. No one of these patients was affected by autoimmune liver disease. No differences were noted between atrophic-erosive OLP (Group 1) and hyperkeratotic OLP (Group 2). This study does not confirm the suggestion that patients with OLP may have a generalized immunologic disorder and it also add some evidences that the role of humoral immunity in the pathogenesis of OLP is probably secondary to the cell-mediated reaction against basal keratinocytes.
对25例萎缩糜烂型口腔扁平苔藓（OLP）患者（第1组）、28例网状斑块样OLP病变患者（第2组）和21例无口腔病变的健康患者（第3组）进行了血清体液免疫参数测定。将萎缩糜烂型OLP患者（第1组）与正常对照组（第3组）进行比较，发现血清IgG水平升高接近统计学意义（Kruskal-Wallis检验p = 0.0572）。还发现，与正常对照组（第3组）相比，萎缩糜烂型OLP患者（第1组）的κ轻链（Kruskal-Wallis检验p = 0.0017；经Bonferroni校正的Mann-Whitney检验p < 0.001）和λ轻链（Kruskal-Wallis检验p = 0.0346；经Bonferroni校正的Mann-Whitney检验p = 0.013）值显著更高。然而，这些较高水平可能是由于萎缩糜烂型OLP患者中慢性肝病的高患病率（40%）所致。这些患者均未患有自身免疫性肝病。萎缩糜烂型OLP（第1组）和角化过度型OLP（第2组）之间未发现差异。本研究未证实OLP患者可能存在全身性免疫紊乱的观点，也增加了一些证据，表明体液免疫在OLP发病机制中的作用可能继发于针对基底角质形成细胞的细胞介导反应。
