Fritsch Rosemarie M, Montt María Elena S, Solís Jaime G, Pilowsky Daniel, Rojas María Graciela C
Hospital Clínico, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Rev Med Chil. 2007 May;135(5):602-12. Epub 2007 Jul 9.
Offspring of depressive parents have two times more risk of developing a depression, other psychiatric diseases or a poor social functioning.
To assess psychopathology and social functioning among offspring of currently depressed mothers.
We enrolled 290 depressed mother-child pairs in five primary-care clinics in Santiago. A two-stage screening process to identify female primary-care patients with current major depressive illness with children aged 6-16 years, was used. AH eligible and consenting patients were asked to complete the general health questionnaire (GHQ-12). Those scoring 5 or more were invited to participate in a baseline assessment. The final sample consisted of 290 mother-child pairs. Patients with a current DSM-IV diagnosis of major depression were eligible unless they had current psychotic symptoms, imminent suicide risk, history of mania, or current alcohol abuse. Child psychopathology was assessed with the Child Behavior Checklist (CBCL), a highly reliable and widely used parent-rated checklist to assess competencies and behavioural and emotional problems in children 4 to 18 years of age.
Fifty percent (95% confidence interval (CI): 43.9-55.7) of children had overall CBCL psychopathology scores in clinical range. Internalizing symptoms were more prevalent than externalizing symptoms (62.2% [9596CI: 56.3-67.8] and 35.7% [9596CI: 30.2-41.5].
A large proportion of children of depressed poor mothers attending primary care clinics in Chile, had psychopathological symptom scores in the clinical range, with a predominance of internalizing symptoms. These results are similar to those previously reported in the United States of America.
患有抑郁症的父母的后代患抑郁症、其他精神疾病或社交功能不良的风险要高出两倍。
评估当前患有抑郁症的母亲的后代的精神病理学和社交功能。
我们在圣地亚哥的五家初级保健诊所招募了290对患有抑郁症的母婴。采用两阶段筛查程序来识别患有当前重度抑郁症且子女年龄在6至16岁的女性初级保健患者。所有符合条件并同意参与的患者被要求完成一般健康问卷(GHQ-12)。得分5分或以上的患者被邀请参加基线评估。最终样本包括290对母婴。患有当前DSM-IV诊断的重度抑郁症的患者符合条件,除非他们有当前的精神病症状、迫在眉睫的自杀风险、躁狂病史或当前的酒精滥用。儿童精神病理学通过儿童行为清单(CBCL)进行评估,这是一种高度可靠且广泛使用的由家长评定的清单,用于评估4至18岁儿童的能力以及行为和情绪问题。
50%(95%置信区间(CI):43.9 - 55.7)的儿童CBCL总体精神病理学得分在临床范围内。内化症状比外化症状更普遍(62.2% [95%CI:56.3 - 67.8] 和35.7% [95%CI:30.2 - 41.5])。
在智利初级保健诊所就诊的贫困抑郁症母亲的很大一部分子女,其精神病理学症状得分在临床范围内,以内化症状为主。这些结果与美国先前报道的结果相似。