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类风湿性关节炎:其成本几何,哪些因素在推动这些成本?瑞典马尔默社区人群的一项调查结果

Rheumatoid arthritis: what does it cost and what factors are driving those costs? Results of a survey in a community-derived population in Malmö, Sweden.

作者信息

Jacobsson L T H, Lindroth Y, Marsal L, Juran E, Bergström U, Kobelt G

机构信息

Department of Rheumatology, Malmö University Hospital, Sweden.

出版信息

Scand J Rheumatol. 2007 May-Jun;36(3):179-83. doi: 10.1080/03009740601089580.

DOI:10.1080/03009740601089580
PMID:17657670
Abstract

OBJECTIVE

We sought to investigate the cost of living with rheumatoid arthritis (RA) and evaluate the influence of both demographics and specific disease characteristics on these costs.

METHODS

We used a population-based questionnaire to survey 895 patients living in the city of Malmö, Sweden, during 2002. Data were obtained on direct resource consumption, investments, informal care and work capacity, as well as utility, function and patients' assessment of disease severity and pain.

RESULTS

The survey was completed by 613 patients (68%). Their mean age was 66 years, 74% were female and the mean duration of disease was 16.7 years. The total mean annual cost per patient was 108,370 SEK (12,020 EUR). Direct costs represented 41% of that amount and were predominantly for drugs [14% of the participants were receiving treatment with tumour necrosis factor (TNF) blockers], community services and hospitalisation. Function measured with the Health Assessment Questionnaire (HAQ) was the main statistical predictor for all types of costs except sick leave, which was most strongly associated with patients' perception of global health.

CONCLUSION

This is the first study in Sweden to include all costs incurred by a group representative of RA in the community. In comparison with previous studies, total costs had increased by more than 40%. Furthermore, direct costs were higher and constituted a great proportion of total costs because of more intensive treatments (i.e. the use of TNF blockers). Future comparisons will enable health economic evaluations on a community level.

摘要

目的

我们试图调查类风湿关节炎(RA)患者的生活成本,并评估人口统计学因素和特定疾病特征对这些成本的影响。

方法

我们使用基于人群的问卷,于2002年对瑞典马尔默市的895名患者进行了调查。获取了有关直接资源消耗、投资、非正式护理和工作能力的数据,以及效用、功能和患者对疾病严重程度和疼痛的评估。

结果

613名患者(68%)完成了调查。他们的平均年龄为66岁,74%为女性,平均病程为16.7年。每位患者的年平均总成本为108,370瑞典克朗(12,020欧元)。直接成本占该金额的41%,主要用于药物(14%的参与者接受肿瘤坏死因子(TNF)阻滞剂治疗)、社区服务和住院治疗。用健康评估问卷(HAQ)测量的功能是除病假外所有类型成本的主要统计预测因素,病假与患者对整体健康的感知最密切相关。

结论

这是瑞典第一项纳入社区中具有RA代表性的一组患者所产生的所有成本的研究。与之前的研究相比,总成本增加了40%以上。此外,由于治疗更加密集(即使用TNF阻滞剂),直接成本更高且占总成本的很大比例。未来的比较将有助于在社区层面进行卫生经济评估。

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