Lin Andrew C, Holt Christine E
Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK.
EMBO J. 2007 Aug 22;26(16):3729-36. doi: 10.1038/sj.emboj.7601808. Epub 2007 Jul 26.
The assembly of functional neural circuits in the developing brain requires neurons to extend axons to the correct targets. This in turn requires the navigating tips of axons to respond appropriately to guidance cues present along the axonal pathway, despite being cellular 'outposts' far from the soma. Work over the past few years has demonstrated a critical role for local translation within the axon in this process in vitro, making axon guidance another process that requires spatially localized translation, among others such as synaptic plasticity, cell migration, and cell polarity. This article reviews recent findings in local axonal translation and discusses how new protein synthesis may function in growth cone guidance, with a comparative view toward models of local translation in other systems.
发育中的大脑中功能性神经回路的组装需要神经元将轴突延伸至正确的靶点。这反过来又要求轴突的导航尖端对轴突路径上存在的导向线索做出适当反应，尽管它们是远离胞体的细胞“前哨”。过去几年的研究表明，轴突内的局部翻译在体外这一过程中起着关键作用，使轴突导向成为另一个需要空间定位翻译的过程，其他过程如突触可塑性、细胞迁移和细胞极性也是如此。本文综述了局部轴突翻译的最新研究成果，并讨论了新蛋白质合成在生长锥导向中可能发挥的作用，同时对其他系统中的局部翻译模型进行了比较。
