Anatomisches Institut - Anatomie und Zellbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Nussallee 10, 53115, Bonn, Germany.
Histochem Cell Biol. 2024 Jan;161(1):5-27. doi: 10.1007/s00418-023-02251-z. Epub 2023 Nov 8.
The present review aims to provide a short update of our understanding of the inhibitory interneurons of the cerebellum. While these cells constitute but a minority of all cerebellar neurons, their functional significance is increasingly being recognized. For one, inhibitory interneurons of the cerebellar cortex are now known to constitute a clearly more diverse group than their traditional grouping as stellate, basket, and Golgi cells suggests, and this diversity is now substantiated by single-cell genetic data. The past decade or so has also provided important information about interneurons in cerebellar nuclei. Significantly, developmental studies have revealed that the specification and formation of cerebellar inhibitory interneurons fundamentally differ from, say, the cortical interneurons, and define a mode of diversification critically dependent on spatiotemporally patterned external signals. Last, but not least, in the past years, dysfunction of cerebellar inhibitory interneurons could also be linked with clinically defined deficits. I hope that this review, however fragmentary, may stimulate interest and help focus research towards understanding the cerebellum.
本综述旨在提供对小脑抑制性神经元的最新认识。虽然这些细胞只占小脑神经元的一小部分，但它们的功能意义越来越受到重视。一方面，小脑皮层的抑制性神经元现在被认为比传统的星形、篮状和高尔基细胞的分组更为多样化，单细胞遗传数据也证实了这一点。在过去的十年左右，人们还获得了关于小脑核内神经元的重要信息。重要的是，发育研究表明，小脑抑制性神经元的特化和形成从根本上不同于皮质神经元，并定义了一种多样化模式，这种模式严重依赖时空模式的外部信号。最后但同样重要的是，在过去的几年中，小脑抑制性神经元的功能障碍也可能与临床上定义的缺陷有关。我希望这个综述，无论多么零碎，都能激发兴趣，并有助于集中研究以了解小脑。
