Sibley Christopher D, Rabin Harvey, Surette Michael G
University of Calgary, Department of Microbiology and Infectious Diseases, Calgary, AB, Canada.
Future Microbiol. 2006 Jun;1(1):53-61. doi: 10.2217/17460913.1.1.53.
Cystic fibrosis (CF) is the most common lethal genetic disease in the Caucasian population, and should be considered an infectious disease because of the basic pathophysiology. Chronic lower airway infections cause a progressive pathologic deterioration of lung tissue, a decline in pulmonary function and, ultimately, respiratory failure and death in 90% of CF patients. Historically, very few bacterial species have been implicated as principal CF pathogens. However, molecular evidence suggests the presence of a diverse mosaic of bacteria in CF lungs, and infections can be defined as polymicrobial. Here we review the work that supports this concept and we discuss the potential significance of the polymicrobial community in lung pathology. Understanding the dynamics of polymicrobial infections, the interplay between pathogen(s), normal oropharyngeal flora and the host immune system may lead to future advances in the therapeutic management of chronic lung infections.
囊性纤维化（CF）是白种人群中最常见的致死性遗传病，由于其基本病理生理学特征，应被视为一种传染病。慢性下呼吸道感染会导致肺组织进行性病理恶化、肺功能下降，最终90%的CF患者会出现呼吸衰竭和死亡。从历史上看，很少有细菌种类被认为是CF的主要病原体。然而，分子证据表明CF肺部存在多种细菌组合，感染可被定义为多重微生物感染。在此，我们综述支持这一概念的研究工作，并讨论多重微生物群落在肺部病理学中的潜在意义。了解多重微生物感染的动态、病原体、正常口咽菌群与宿主免疫系统之间的相互作用，可能会为慢性肺部感染的治疗管理带来未来的进展。
