Ingelfinger J R, McCluskey R T, Schneeberger E E, Grupe W E
J Pediatr. 1977 Aug;91(2):228-32. doi: 10.1016/s0022-3476(77)80817-2.
A patient with biopsy documented acute poststreptococcal glomerulonephritis and arteritis recovered completely with supportive therapy. Illness was preceded by group A streptococcal pharyngitis. At the time of presentation, serum creatinine concentration was 11.5 mg/dl. Serum cryoglobulins containing IgG and C3 were present. The first biopsy, performed during the acute illness, contained glomeruli with typical features of acute PSGN. Medium-sized arteries had extensive necrosis and leukocytic infiltration, and contained IgG, C3, and fibrin. Glomerular filtration rate returned to normal within three weeks; proteinuria cleared by three months, and microscopic hematuria by 11 months. Renal biopsy one year later showed minimal mesangial hypercellularity and no arteritis.
一名经活检证实患有急性链球菌感染后肾小球肾炎和动脉炎的患者通过支持性治疗完全康复。发病前有A组链球菌性咽炎。就诊时血清肌酐浓度为11.5mg/dl。存在含有IgG和C3的血清冷球蛋白。在急性疾病期间进行的首次活检显示肾小球具有急性链球菌感染后肾小球肾炎的典型特征。中等大小动脉有广泛坏死和白细胞浸润，并含有IgG、C3和纤维蛋白。肾小球滤过率在三周内恢复正常；蛋白尿在三个月内消失，镜下血尿在11个月内消失。一年后的肾活检显示系膜细胞轻度增生，无动脉炎。
