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普通人群中的职业与成人鼻炎发病情况。

Occupation and adult onset of rhinitis in the general population.

作者信息

Radon K, Gerhardinger U, Schulze A, Zock J-P, Norback D, Toren K, Jarvis D, Held L, Heinrich J, Leynaert B, Nowak D, Kogevinas M

机构信息

Unit for Occupational and Environmental Epidemiology & Net Teaching, Institute and Outpatient Clinic for Occupational and Environmental Medicine, Ziemssenstr 1, D-80336 Munich, Germany.

出版信息

Occup Environ Med. 2008 Jan;65(1):38-43. doi: 10.1136/oem.2006.031542. Epub 2007 Jul 30.

Abstract

OBJECTIVES

Occupational exposures have been associated with an increased risk of new-onset rhinitis in apprentices. However, population-based prospective data are scarce and do not cover new onset of rhinitis later in life. The authors studied the association between occupational exposure and adult onset of rhinitis prospectively.

METHODS

The data of 4994 participants (age at follow-up 28-57 years) from 27 centres of the European Community Respiratory Health Survey II who were symptom-free at baseline were analysed. As outcome at follow-up self-reported (a) nasal allergies ("allergic rhinitis") and (b) runny, blocked nose for 12 months a year ("perennial rhinitis") were used. Occupational exposures at any time during follow-up were defined by job title.

RESULTS

The cumulative incidence of allergic rhinitis, perennial rhinitis and both conditions was 12%, 11% and 3%, respectively. Compared to office workers, male medical professionals were at increased risk of new onset of allergic rhinitis (OR 3.0; 95% CI 1.4 to 6.4). Odds ratios were reduced in metal workers not involved in metal making or treating (0.3; 95% CI 0.1 to 0.7). For perennial rhinitis ORs were significantly increased in cleaners (1.4; 95% CI 1.0 to 2.1).

CONCLUSIONS

Cleaners and medical professionals may be at increased risk for adult-onset rhinitis.

摘要

目的

职业暴露与学徒中新发鼻炎风险增加有关。然而,基于人群的前瞻性数据稀缺,且未涵盖晚年新发鼻炎情况。作者前瞻性地研究了职业暴露与成人期鼻炎发病之间的关联。

方法

对来自欧洲共同体呼吸健康调查II的27个中心的4994名参与者(随访时年龄28 - 57岁)的数据进行分析,这些参与者在基线时无症状。随访时的结局采用自我报告的(a)鼻过敏(“过敏性鼻炎”)和(b)每年流鼻涕、鼻塞12个月(“常年性鼻炎”)。随访期间任何时候的职业暴露通过职业头衔定义。

结果

过敏性鼻炎、常年性鼻炎以及两种情况的累积发病率分别为12%、11%和3%。与办公室职员相比,男性医疗专业人员新发过敏性鼻炎的风险增加(比值比3.0;95%置信区间1.4至6.4)。未参与金属制造或处理的金属工人的比值比降低(0.3;95%置信区间0.1至0.7)。对于常年性鼻炎,清洁工的比值比显著增加(1.4;95%置信区间1.0至2.1)。

结论

清洁工和医疗专业人员成人期鼻炎发病风险可能增加。

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