Wieland Catharina W, Florquin Sandrine, van der Poll Tom
Center of Infection and Immunity, G2-132, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Infect Immun. 2007 Oct;75(10):5068-72. doi: 10.1128/IAI.00287-07. Epub 2007 Jul 30.
Nontypeable Haemophilus influenzae (NTHi) is a common gram-negative respiratory pathogen. To determine the role of the proinflammatory cytokine interleukin 18 (IL-18) during NTHi pneumonia, normal wild-type (WT) and IL-18 knockout (KO) mice were intranasally infected with NTHi. IL-18 KO mice displayed a delayed clearance of NTHi from the respiratory tract, resulting in >20-fold higher bacterial loads in their lungs at 24 h after infection, preceded by a strongly attenuated pulmonary innate immune response as determined by cytokine and chemokine induction and histopathology. These data identify IL-18 as part of an adequate innate immune response during NTHi pneumonia.
不可分型流感嗜血杆菌（NTHi）是一种常见的革兰氏阴性呼吸道病原体。为了确定促炎细胞因子白细胞介素18（IL-18）在NTHi肺炎中的作用，将正常野生型（WT）小鼠和IL-18基因敲除（KO）小鼠经鼻内感染NTHi。IL-18基因敲除小鼠呼吸道中NTHi的清除延迟，导致感染后24小时其肺部细菌载量高出20倍以上，在此之前，通过细胞因子和趋化因子诱导以及组织病理学测定，其肺部固有免疫反应强烈减弱。这些数据表明IL-18是NTHi肺炎期间适当固有免疫反应的一部分。
