维生素E对更年期女性潮热的影响。
The effect of vitamin E on hot flashes in menopausal women.
作者信息
Ziaei S, Kazemnejad A, Zareai M
机构信息
Faculty of Medical Science, Tarbiat Modarres University, Tehran, Iran.
出版信息
Gynecol Obstet Invest. 2007;64(4):204-7. doi: 10.1159/000106491. Epub 2007 Jul 30.
BACKGROUND
Hot flashes affect as many as 75% of menopausal women. Estrogen reliably reduces the severity of hot flashes and remain the single most effective treatment. Today, however, more and more women are seeking alternatives. Instead of hormonal therapy, women are turning to vitamins, and other over-the-counter products for relief from hot flashes. This study was undertaken to assess the effect of vitamin E on hot flashes.
METHOD
A placebo double blind-controlled trial was conducted. After 1 week baseline period, the enrolled patients (n = 51) received placebo (identical in appearance to vitamin E softgel) daily for 4 weeks, followed by 1 week wash out and 400 IU vitamin E (softgel cap) daily for the next 4 weeks. Diary was used to measure hot flashes before and at the end of the study.
RESULT
There were statistical significant differences in hot flashes severity score (2.37 +/- 0.74, 1.80 +/- 0.87) and their daily frequency (5.00 +/- 3.34, 3.19 +/- 2.74) after the treatments between the placebo and vitamin E therapies (p < 0.0001).
CONCLUSION
Based on our trial, vitamin E is recommended for the treatment of hot flashes.
背景
潮热影响多达75%的绝经后女性。雌激素能可靠地减轻潮热的严重程度，仍然是最有效的单一治疗方法。然而，如今越来越多的女性在寻求替代方法。女性不再采用激素疗法，而是转向维生素及其他非处方产品来缓解潮热。本研究旨在评估维生素E对潮热的影响。
方法
进行了一项安慰剂双盲对照试验。在1周的基线期后，纳入的患者（n = 51）每天服用安慰剂（外观与维生素E软胶囊相同），持续4周，随后有1周的洗脱期，接下来的4周每天服用400 IU维生素E（软胶囊）。通过日记记录来测量研究开始前和结束时的潮热情况。
结果
安慰剂治疗和维生素E治疗后，潮热严重程度评分（2.37 ± 0.74，1.80 ± 0.87）及其每日发作频率（5.00 ± 3.34，3.19 ± 2.74）存在统计学显著差异（p < 0.0001）。
结论
基于我们的试验，推荐使用维生素E治疗潮热。
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