SRY与性别决定中的僵持局面。
SRY and the standoff in sex determination.
作者信息
DiNapoli Leo, Capel Blanche
机构信息
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Mol Endocrinol. 2008 Jan;22(1):1-9. doi: 10.1210/me.2007-0250. Epub 2007 Jul 31.
Abstract
SRY was identified as the mammalian sex-determining gene more than 15 yr ago and has been extensively studied since. Although many of the pathways regulating sexual differentiation have been elucidated, direct downstream targets of SRY are still unclear, making a top down approach difficult. However, recent work has demonstrated that the fate of the gonad is actively contested by both male-promoting and female-promoting signals. Sox9 and Fgf9 push gonads towards testis differentiation. These two genes are opposed by Wnt4, and possibly RSPO1, which push gonads toward ovary differentiation. In this review, we will discuss the history of the field, current findings, and exciting new directions in vertebrate sex determination.
摘要
15年多前，SRY被确定为哺乳动物的性别决定基因，自那时起就得到了广泛研究。尽管许多调节性别分化的途径已被阐明，但SRY的直接下游靶点仍不清楚，这使得自上而下的研究方法变得困难。然而，最近的研究表明，性腺的命运受到促进雄性和促进雌性信号的积极竞争。Sox9和Fgf9促使性腺向睾丸分化。这两个基因受到Wnt4以及可能还有RSPO1的拮抗，Wnt4和RSPO1促使性腺向卵巢分化。在这篇综述中，我们将讨论该领域的历史、当前的研究发现以及脊椎动物性别决定中令人兴奋的新方向。
相似文献
1
SRY and the standoff in sex determination.
Mol Endocrinol. 2008 Jan;22(1):1-9. doi: 10.1210/me.2007-0250. Epub 2007 Jul 31.
2
Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development?
Semin Cell Dev Biol. 2017 Mar;63:13-22. doi: 10.1016/j.semcdb.2016.07.032. Epub 2016 Jul 29.
3
Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.
PLoS Biol. 2006 Jun;4(6):e187. doi: 10.1371/journal.pbio.0040187. Epub 2006 May 23.
4
Gadd45g is required for timely Sry expression independently of RSPO1 activity.
Reproduction. 2022 Apr 22;163(6):333-340. doi: 10.1530/REP-21-0443.
5
Different levels of testicular organization during gonadal differentiation in B6.Y(Tir) mice manifesting sex reversal.
Cell Biol Int. 2012 Sep;36(9):811-22. doi: 10.1042/CBI20110653.
6
WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.
Development. 2012 Dec 1;139(23):4461-72. doi: 10.1242/dev.078972. Epub 2012 Oct 24.
7
Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem.
Dev Dyn. 2006 Sep;235(9):2292-300. doi: 10.1002/dvdy.20894.
8
Expression profiles of SRY and SOX9 in rabbit gonads: the classical model of mammalian sex differentiation.
Sex Dev. 2008;2(3):152-66. doi: 10.1159/000143433. Epub 2008 Sep 3.
9
A critical time window of Sry action in gonadal sex determination in mice.
Development. 2009 Jan;136(1):129-38. doi: 10.1242/dev.029587. Epub 2008 Nov 26.
10
CDYL reinforces male gonadal sex determination through epigenetically repressing transcription in mice.
Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2221499120. doi: 10.1073/pnas.2221499120. Epub 2023 May 8.
引用本文的文献
1
Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep.
Mol Cell Endocrinol. 2024 Jul 1;588:112234. doi: 10.1016/j.mce.2024.112234. Epub 2024 Apr 6.
2
Analysis of a Yp11.2 region deletion in a Chinese female with Turner syndrome: A case report.
Heliyon. 2023 Apr 3;9(4):e15162. doi: 10.1016/j.heliyon.2023.e15162. eCollection 2023 Apr.
3
Impact of endocrine disrupting chemicals and pharmaceuticals on Sertoli cell development and functions.
Front Endocrinol (Lausanne). 2023 Jan 30;14:1095894. doi: 10.3389/fendo.2023.1095894. eCollection 2023.
4
SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation.
Mol Neurobiol. 2021 Jun;58(6):2634-2642. doi: 10.1007/s12035-020-02240-6. Epub 2021 Jan 22.
5
Doublesex controls specification and maintenance of the gonad stem cell niches in .
Development. 2019 Jun 10;146(11):dev170001. doi: 10.1242/dev.170001.
6
Translating genomics to the clinical diagnosis of disorders/differences of sex development.
Curr Top Dev Biol. 2019;134:317-375. doi: 10.1016/bs.ctdb.2019.01.005. Epub 2019 Mar 20.
7
Advanced immunostaining approaches to study early male germ cell development.
Stem Cell Res. 2018 Mar;27:162-168. doi: 10.1016/j.scr.2018.01.031. Epub 2018 Feb 9.
8
Proper diagnosis and management of nonobstructive azoospermia: NYU Case of the Month, June 2017.
Rev Urol. 2017;19(2):142-144. doi: 10.3909/riu0764.
9
Dmrt1 is required for primary male sexual differentiation in Chinese soft-shelled turtle Pelodiscus sinensis.
Sci Rep. 2017 Jun 30;7(1):4433. doi: 10.1038/s41598-017-04938-5.
10
Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats.
Sci Rep. 2017 May 31;7(1):2521. doi: 10.1038/s41598-017-02684-2.
本文引用的文献
1
Expression and biological role of the prostaglandin D synthase/SOX9 pathway in human ovarian cancer cells.
Cancer Lett. 2007 Oct 8;255(2):182-93. doi: 10.1016/j.canlet.2007.04.007. Epub 2007 May 29.
2
Recurrent SOX9 deletion campomelic dysplasia due to somatic mosaicism in the father.
Am J Med Genet A. 2007 Apr 15;143A(8):866-70. doi: 10.1002/ajmg.a.31631.
3
Expression of Sox9, Mis, and Dmrt1 in the gonad of a species with temperature-dependent sex determination.
Dev Dyn. 2007 Apr;236(4):1055-63. doi: 10.1002/dvdy.21096.
4
SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development.
J Biol Chem. 2007 Apr 6;282(14):10553-60. doi: 10.1074/jbc.M609578200. Epub 2007 Feb 2.
5
R-spondin1 is essential in sex determination, skin differentiation and malignancy.
Nat Genet. 2006 Nov;38(11):1304-9. doi: 10.1038/ng1907. Epub 2006 Oct 15.
6
Exploring the evolution of environmental sex determination, especially in reptiles.
J Evol Biol. 2006 Nov;19(6):1775-84. doi: 10.1111/j.1420-9101.2006.01138.x.
7
Genomic evolution of Hox gene clusters.
Science. 2006 Sep 29;313(5795):1918-22. doi: 10.1126/science.1132040.
8
Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.
PLoS Biol. 2006 Jun;4(6):e187. doi: 10.1371/journal.pbio.0040187. Epub 2006 May 23.
9
Retinoid signaling determines germ cell fate in mice.
Science. 2006 Apr 28;312(5773):596-600. doi: 10.1126/science.1125691. Epub 2006 Mar 30.
10
FGF9 promotes survival of germ cells in the fetal testis.
Development. 2006 Apr;133(8):1519-27. doi: 10.1242/dev.02303. Epub 2006 Mar 15.
Zotero 插件