携带细胞毒素相关基因A的幽门螺杆菌菌株与缺血性起源的心房颤动：存在关联吗？
Cytotoxin-associated gene-A bearing strains of Helicobacter pylori and atrial fibrillation due to ischemic origin: is there a link?
作者信息
Badran Hala Mahfouz, Mahfouz Magdi Elsayed
机构信息
Cardiology Department, Faculty of Medicine, Menoufiya University, Shebin El-Koom, Egypt.
出版信息
Eur J Cardiovasc Prev Rehabil. 2007 Aug;14(4):518-20. doi: 10.1097/HJR.0b013e328011a2a0.
BACKGROUND
Helicobacter pyloriCagA strains could increase the risk for atrial fibrillation in patients with coronary artery disease
METHODS
Serological status for H. pyloriCagA using enzyme-linked immunosorbent assay, C-reactive protein, total leucocytic count and atrial size were determined in 185 coronary artery disease patients (with and without atrial fibrillation) and 80 healthy subjects (control).
RESULTS
CagA strain showed a higher prevalence in the atrial fibrillation group. Atrial dimension and C-reactive protein (independent predictors of atrial fibrillation) were significantly increased in the CagA seropositive subgroup
CONCLUSIONS
There is a strong liaison between H. pylori CagA infection and atrial fibrillation in coronary artery disease. Increased C reactive protein and atrial size in atrial fibrillation patients may reflect atrial inflammatory remodeling.
背景
幽门螺杆菌CagA菌株可增加冠心病患者发生心房颤动的风险
方法
采用酶联免疫吸附测定法测定185例冠心病患者（有或无心房颤动）和80例健康受试者（对照组）的幽门螺杆菌CagA血清学状态、C反应蛋白、白细胞总数和心房大小。
结果
CagA菌株在心房颤动组中的患病率较高。在CagA血清阳性亚组中，心房大小和C反应蛋白（心房颤动的独立预测指标）显著增加。
结论
幽门螺杆菌CagA感染与冠心病患者的心房颤动之间存在密切联系。心房颤动患者C反应蛋白增加和心房增大可能反映了心房炎症重塑。
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