Wang De-Zhao, Chen Wei, Yang Song, Wang Jun, Li Qun, Fu Qiang, Li Shi-Jing, Chen Bu-Xing
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Department of Ultrasonography, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Clin Interv Aging. 2015 Apr 28;10:813-9. doi: 10.2147/CIA.S72724. eCollection 2015.
To explore the relationship between Helicobacter pylori (Hp) infection and atrial fibrillation (AF) in Chinese patients.
A total of 285 hospitalized patients with AF and 300 patients from Health Screening Center who matched age and sex with AF group were enrolled. AF patients were divided into two groups: the short-standing AF category (less than a year) and the long-standing AF category (more than a year). All patients had laboratory testing of (13)C urea breath test, high-sensitive C-reactive protein (hs-CRP) and left atrial diameter (LAD). We analyzed the difference of these factors in all groups and explored the correlation between Hp infection and AF using logistic regression analysis.
Both AF groups had more hypertension, diabetes, and Hp infection than the control group. The Hp value and the hs-CRP level in patients with long-standing AF were higher than those in the short-standing AF and the control groups (for Hp value: P<0.001 for both and for hs-CRP level: P=0.003, 0.002, respectively). The LAD of patients in the long-standing AF group was significantly larger than those in the short-standing AF group and control group (P=0.001 and P<0.001, respectively). The values of Hp, hs-CRP, and LAD in the long-standing AF category were significantly higher than those in the short-standing AF category (all P<0.05). After controlling the potential confounders, Hp value ≥4‰, hs-CRP >5 mg/L, and LAD >36 mm were significantly related to long-standing AF.
The values of Hp in patients with long-standing AF were significantly higher than those in short-standing AF and control groups. Hp δ value ≥4‰ is an independent predictor for long-standing AF.
探讨中国患者幽门螺杆菌（Hp）感染与心房颤动（AF）之间的关系。
共纳入285例住院AF患者以及300例来自健康体检中心、年龄和性别与AF组相匹配的患者。AF患者分为两组：短期AF组（少于1年）和长期AF组（超过1年）。所有患者均进行了（13）C尿素呼气试验、高敏C反应蛋白（hs-CRP）和左心房直径（LAD）的实验室检测。我们分析了所有组中这些因素的差异，并使用逻辑回归分析探讨Hp感染与AF之间的相关性。
两个AF组的高血压、糖尿病和Hp感染均比对照组更多。长期AF患者的Hp值和hs-CRP水平高于短期AF组和对照组（Hp值：两组均P<0.001；hs-CRP水平：分别为P=0.003、0.002）。长期AF组患者的LAD明显大于短期AF组和对照组（分别为P=0.001和P<0.001）。长期AF组的Hp、hs-CRP和LAD值明显高于短期AF组（均P<0.05）。在控制潜在混杂因素后，Hp值≥4‰、hs-CRP>5mg/L和LAD>36mm与长期AF显著相关。
长期AF患者的Hp值明显高于短期AF组和对照组。Hpδ值≥4‰是长期AF的独立预测因素。
