Liu Wei, Cao Yilin
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, National Tissue Engineering Center of China, 639 Zhi Zao Ju Road, Shanghai 200011, PR China.
Biomaterials. 2007 Dec;28(34):5078-86. doi: 10.1016/j.biomaterials.2007.07.028. Epub 2007 Jul 31.
In spite of many researches on scaffold material design, fabrication and characterization, as well as cell-material interaction in vitro, in vivo study especially in large mammals should be an essential step towards practical application. In our center, different scaffold materials have been applied to the reconstruction of various types of tissues using immunocompetent mammals as major animal models, such as for reconstruction of bone, cartilage, tendon, skin, blood vessel and corneal stroma, etc. In this article, our experience, as well as encountered challenges in the application of scaffold materials, is introduced. Additionally, future requirements for scaffold application in tissue reconstruction and regeneration are proposed as well.
尽管在支架材料的设计、制造和表征以及体外细胞与材料相互作用方面进行了许多研究，但体内研究，尤其是在大型哺乳动物中的研究，应该是迈向实际应用的关键一步。在我们中心，已经将不同的支架材料应用于使用具有免疫活性的哺乳动物作为主要动物模型的各种组织的重建，例如用于骨、软骨、肌腱、皮肤、血管和角膜基质等的重建。在本文中，介绍了我们在支架材料应用方面的经验以及遇到的挑战。此外，还提出了支架在组织重建和再生中应用的未来要求。
