Bolner A, Valentini A, Ambrosini G, Amichetti M, Borriello G, Busana L, Fellin G, Graiff C, Nassivera E, Pani G
U.O. di Radioterapia, Ospedale S. Chiara, Trento.
Radiol Med. 1991 Oct;82(4):493-9.
A rectrospective analysis was performed of the results of 104 consecutive patients with carcinoma of the pyriform sinus, who underwent radiation therapy. Thirty-four patients underwent radical surgery and postoperative radiation therapy (group 1); 36 patients received radical radiation therapy alone (group 2); neoadjuvant chemotherapy was administered prior to full-dose radiation to 20 patients (group 3); 14 patients received palliative radiation therapy (group 4). Loco-regional control and survival rates at 5 years were 60.4% and 34.3% in group 1, 23.8% and 23.8% in group 2, 17.5% and 23.8% in group 3; no patients in group 4 survived at 5 years. Patients in group 1 experienced significantly better survival and local control than those in groups 2 and 3. No differences were observed between groups 2 and 3. Loco-regional recurrence was the main cause of failure in group 2 (69.4%) and 3 (70.0%). In group 1, 20.3% of cases developed distant metastases. Overall 5-year survival rate was 23.7%, confirming the poor prognosis of this disease. These results provide further support to the need of improving prevention and early diagnosis to improve both results and outcome in patients with carcinoma of the pyriform sinus.
对104例连续接受放射治疗的梨状窦癌患者的结果进行了回顾性分析。34例患者接受了根治性手术及术后放射治疗（第1组）；36例患者仅接受了根治性放射治疗（第2组）；20例患者在全剂量放疗前接受了新辅助化疗（第3组）；14例患者接受了姑息性放射治疗（第4组）。第1组的局部区域控制率和5年生存率分别为60.4%和34.3%，第2组为23.8%和23.8%，第3组为17.5%和23.8%；第4组无患者存活至5年。第1组患者的生存率和局部控制情况明显优于第2组和第3组。第2组和第3组之间未观察到差异。局部区域复发是第2组（69.4%）和第3组（70.0%）治疗失败的主要原因。在第1组中，20.3%的病例发生了远处转移。总体5年生存率为23.7%，证实了该疾病预后较差。这些结果进一步支持了需要改进预防和早期诊断，以改善梨状窦癌患者的治疗效果和结局。
