117例梨状窦癌的放射治疗结果

[Results of radiotherapy in 117 cases of carcinoma of pyriform sinuses].

作者信息

Ramos Fernández J, Avilés Mañoso P, Martín Atienza R, Lozano Barriuso M A, Fernández-Vega M

机构信息

Servicio de ORL, Hospital General Gregorio Marañón, Universidad Complutense, Madrid.

出版信息

Acta Otorrinolaringol Esp. 1994 May-Jun;45(3):185-90.

PMID:8068362

Abstract

A retrospective study was made of 117 cases of squamous cell carcinoma of the pyriform sinus treated with radiation therapy (RTX). Sixty-three patients underwent radical RTX (group I) and 54 patients received combined treatment (group II). Adjuvant chemotherapy (QTX) was applied in 36 patients (27 of group I, 9 of group II). Residual disease after treatment was observed in 35% (group I) and 4% (group II) (p < 0.001). The rates of local and/or regional recurrence were 46% and 38% respectively. Distant metastases were found in 6% (group I) and 20% (group II) (p < 0.05). The 5-year actuarial survival rates were 23% (group I) and 35% (group II). The group I patients who received QTX had better survival rates (41%) than those who did not (13%) (p < 0.05). The group II survival was not improved by QTX.

摘要

对117例接受放射治疗（RTX）的梨状窝鳞状细胞癌患者进行了回顾性研究。63例患者接受了根治性RTX（第一组），54例患者接受了联合治疗（第二组）。36例患者（第一组27例，第二组9例）接受了辅助化疗（QTX）。治疗后残留病灶在第一组为35%，在第二组为4%（p<0.001）。局部和/或区域复发率分别为46%和38%。远处转移在第一组为6%，在第二组为20%（p<0.05）。5年精算生存率在第一组为23%，在第二组为35%。接受QTX的第一组患者生存率（41%）高于未接受QTX的患者（13%）（p<0.05）。QTX未改善第二组的生存率。