Källberg M, Lindén L, Gustafson A
Scand J Clin Lab Invest. 1976 Jan;36(1):59-65. doi: 10.3109/00365517609068019.
The appearance of additional lipoprotein fractions with pre-beta-mobility on cellulose acetate and agarose gel electrophoresis has recently been linked with the early occurrence of ischemic heart disease (IHD). One of these fractions, designated sinking pre-beta-lipoprotein (SPB) has been isolated, purified, and identififed as synonymous with LP(a). In the present study, the lipid moieties of this lipoprotein fraction were further characterized as to their fatty acid composition. These were almost identical to those of low-density lipoprotein (LDL) lipid moieties. The acute influence on fatty acid composition of SPB lipid moieties, 5 hr after a linoleic acid-rich test meal, was a 40% increase in triglyceride linoleic acid content and only minor changes in phosphoglyceride fatty acids. Data speak against an actual conversion of chylomicron remnants into SPB but would allow a certain exchange of lipid moiety among chylomicrons, SPB, and LDL. It is therefore suggested that the origin of the SPB presumably synonymous with LP(a) is the same as for LDL: the liver.
最近，在醋酸纤维素和琼脂糖凝胶电泳上出现的具有前β迁移率的额外脂蛋白组分与缺血性心脏病（IHD）的早期发生有关。其中一种组分，称为下沉前β脂蛋白（SPB），已被分离、纯化，并被鉴定为与LP(a)同义。在本研究中，该脂蛋白组分的脂质部分在脂肪酸组成方面得到了进一步表征。这些与低密度脂蛋白（LDL）脂质部分的脂肪酸组成几乎相同。富含亚油酸的试验餐5小时后，对SPB脂质部分脂肪酸组成的急性影响是甘油三酯亚油酸含量增加40%，而磷脂脂肪酸仅有轻微变化。数据表明乳糜微粒残粒不会实际转化为SPB，但允许在乳糜微粒、SPB和LDL之间进行一定程度的脂质部分交换。因此，有人提出，可能与LP(a)同义的SPB的起源与LDL相同：肝脏。
