Mittelbronn Michel, Simon Perikles, Löffler Christian, Capper David, Bunz Benedikt, Harter Patrick, Schlaszus Holger, Schleich Ariane, Tabatabai Ghazaleh, Goeppert Benjamin, Meyermann Richard, Weller Michael, Wischhusen Jörg
Institute of Brain Research, University of Tuebingen, Calwerstr. 3, D-72076 Tuebingen, Germany.
J Neuroimmunol. 2007 Sep;189(1-2):50-8. doi: 10.1016/j.jneuroim.2007.07.002. Epub 2007 Aug 1.
HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8(+) immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration.
HLA-E是自然杀伤细胞（NK）和T细胞上表达的免疫抑制性NKG2A受体的配体。为了在体内研究人星形细胞瘤中HLA-E的表达及免疫细胞浸润情况，我们通过免疫组织化学分析了所有WHO分级的正常中枢神经系统对照组织和星形细胞瘤。星形细胞瘤中CD8(+)免疫细胞浸润和HLA-E表达均显著高于正常脑组织。此外，在WHO Ⅳ级胶质母细胞瘤中，HLA-E表达水平与免疫细胞浸润显著相关。因此，胶质母细胞瘤中HLA-E的过表达可能由T细胞和NK细胞浸润触发。
