Katsumi T, Murayama K, Tajika E, Nakamura T, Kawaguchi K
Department of Urology, Kanazawa National Hospital.
Hinyokika Kiyo. 1991 Nov;37(11):1575-80.
The clinical effectiveness and safety of terodiline hydrochloride and clenbuterol hydrochloride were studied on 51 patients with neurogenic bladder, stress incontinence, unstable bladder and others, the chief complaints of which were urinary frequency or urinary incontinence. Overall improvement was graded as marked in 6 patients (11.8%), moderate in 20 patients (39.2%), slight in 11 patients (21.6%), unchanged in 13 patients (25.5%) and aggravated in one. The patients impression was "good" or better in 56.9%. There were a total of 13 cases (25.5%) of adverse reactions, namely, 7 cases of finger tremor, 3 cases of dry mouth and others. These reactions disappeared rapidly after the discontinuance of drug administration. The clinical efficacy in the treatment of subjective symptoms was 71.4% for urinary incontinence, 56.4% for diurnal pollakisuria. The examination of lower urethral functions demonstrated a significant (p less than 0.01) increase in bladder capacity at first desire and maximum desire to void. However, we found no significant increase in urethral clossure pressure. The findings of this study suggest that terodiline hydrochloride and clenbuterol hydrochloride are very useful for the treatment of urinary frequency and incontinence.
对51例患有神经源性膀胱、压力性尿失禁、不稳定膀胱等疾病（主要症状为尿频或尿失禁）的患者，研究了盐酸特罗地林和盐酸克伦特罗的临床有效性和安全性。总体改善情况分级为：显著改善6例（11.8%），中度改善20例（39.2%），轻度改善11例（21.6%），无变化13例（25.5%），病情加重1例。患者评价为“良好”或更好的占56.9%。共有13例（25.5%）出现不良反应，即手指震颤7例、口干3例等。停药后这些反应迅速消失。治疗主观症状的临床有效率为：尿失禁71.4%，日间尿频56.4%。下尿道功能检查显示，首次有排尿欲望和最大排尿欲望时膀胱容量显著增加（p<0.01）。然而，我们发现尿道闭合压没有显著增加。本研究结果表明，盐酸特罗地林和盐酸克伦特罗对治疗尿频和尿失禁非常有用。
