Tsujimoto Y, Fujisue H, Shima H, Ikoma F, Sakurai T, Sato Y, Tokizane M, Akiyama K, Kato S, Nakachi K
Department of Urology, Hyogo College of Medicine.
Hinyokika Kiyo. 1988 Apr;34(4):724-32.
We evaluated the effectiveness and side effects of long-term administration of terodiline hydrochloride in patients with chief complaints of pollakisuria or incontinence or both due to unstable bladder or neurogenic bladder associated with uninhibited contraction. The dose was 24 mg once daily. The symptoms such as pollakisuria and incontinence improved in 31 out of 41 patients (76%). Mild side effects were observed in 12 out of 47 patients (26%), which were thirst, dizziness, dysuria, urticaria and gastrointestinal symptoms. An increasing tendency of both maximum desire to void and compliance (p less than 0.10), and significant difference in maximum static pressure (p less than 0.05) were observed on urodynamic examinations before and after administration of this medicine. The results obtained from this study suggest that terodiline hydrochloride may be greatly recommended for patients with such symptoms as pollakisuria and incontinence.
我们评估了长期服用盐酸特罗地林对因膀胱不稳定或与无抑制性收缩相关的神经源性膀胱而主诉尿频、尿失禁或两者皆有的患者的有效性和副作用。剂量为每日一次24毫克。41名患者中有31名（76%）的尿频和尿失禁等症状得到改善。47名患者中有12名（26%）出现轻度副作用，包括口渴、头晕、排尿困难、荨麻疹和胃肠道症状。用药前后的尿动力学检查显示，最大排尿欲望和顺应性均有增加趋势（p小于0.10），最大静息压力有显著差异（p小于0.05）。本研究结果表明，盐酸特罗地林可能非常适合有尿频和尿失禁等症状的患者。
