Yoneyama T, Ogawa A, Fukui J, Wajiki M, Tomita Y, Igawa Y, Yanagisawa A, Uchiyama S, Watanabe K, Aida Y
Hinyokika Kiyo. 1987 Feb;33(2):319-26.
The clinical effect of terodiline hydrochloride (TD-758) was studied in 95 patients with nervous pollakisuria or irritative bladder. TD-758 was given per os randomly at a dose of 24 mg or 12 mg once a day for 4 weeks. The symptoms such as urinary frequency, urinary incontinence and sense of residual urine were improved in 74% of the patients taking 24 mg, and in 51% of the patients taking 12 mg. The difference was statistically significant. Side effects such as dry mouth, constipation and heart burn were observed in 15% of the patients in each group and were not serious. The results of this study indicate that TD-758 is useful for these patients and its optimal dosage is 24 mg once a day.
对95例神经性尿频或膀胱刺激症患者研究了盐酸特罗地林（TD - 758）的临床疗效。TD - 758以24毫克或12毫克的剂量随机口服给药，每日1次，共4周。服用24毫克的患者中74%的尿频、尿失禁及残余尿感等症状得到改善，服用12毫克的患者中这一比例为51%。差异具有统计学意义。每组15%的患者出现口干、便秘和烧心等副作用，且不严重。本研究结果表明，TD - 758对这些患者有效，其最佳剂量为每日24毫克。
