Yasuno H, Ogawa T, Arakawa S, Matsumoto O, Kamidono S, Kataoka N, Matsushita M, Inaba Y, Umezu K, Yamashita M
Department of Urology, Kobe University School of Medicine.
Hinyokika Kiyo. 1991 Apr;37(4):431-9.
A clinical trial with the collaboration of 15 department of urology was performed to determine the usefulness of terodiline hydrochloride in 99 patients whose chief complaints were of pollakisuria or incontinence due to neurogenic bladder, psychogenic disease or chronic cystitis. The patients were orally given 24 mg once daily for 4 weeks. The final global improvement rate was 88.5% and the effective rates on subjective symptoms were; 66.2% for diurnal urinary frequency, 68.0% for nocturnal urinary frequency, 68.8% for urinary incontinence and 78.3% for nocturnal enuresis. Even for the cases having mild bladder outlet obstructive disease, the clinical effective rates were good. Mild side effects were observed in 10 patients, which were dry mouth and others. The results obtained from this trial suggest that terodiline hydrochloride may be useful for the treatment of urinary frequency and incontinence caused by detrusor instability.
一项由15个泌尿外科科室合作开展的临床试验，旨在确定盐酸特罗地林对99例主要因神经源性膀胱、精神性疾病或慢性膀胱炎而出现尿频或尿失禁的患者的有效性。患者每日口服一次24毫克，持续4周。最终总体改善率为88.5%，主观症状的有效率分别为：日间尿频66.2%，夜间尿频68.0%，尿失禁68.8%，夜间遗尿78.3%。即使对于轻度膀胱出口梗阻性疾病的病例，临床有效率也较好。10例患者出现轻度副作用，包括口干等。该试验结果表明，盐酸特罗地林可能对治疗逼尿肌不稳定引起的尿频和尿失禁有效。
