Hsu H Y, Ho Y H, Lian S L, Lin C C
School of Technology for Medical Sciences, Kaohsiung Medical College, Taiwan.
Am J Chin Med. 1991;19(3-4):275-84. doi: 10.1142/S0192415X91000363.
In order to evaluate the potential action of Kuei-Pi-Tang as an antiradiation agent, colony forming units of bone marrow cells in the spleen (CFUs) were used. Different sequences of X-ray irradiation with or without Kuei-Pi-Tang administration in the groups of ICR strain mice were intraperitoneally injected 10mg/20g or 20mg/20g, once a day, for consecutive seven days before or after 4Gy X-ray irradiation. After the different treatments, whole blood was collected from the tail endings to observe the fluctuation of leukocytes, erythrocytes and thrombocytes. The administration of 20mg/20g was more effective than that of 10mg/20g. Lower radiosensitivity was observed with the treatment of 20mg/20g of Kui-Pi-Tang than that of 10mg/20g. The injection of Kuei-Pi-Tang accelerated the recovery of blood cell counts of leukocytes, erythrocytes and thrombocytes in mice irradiated with 4Gy, especially for leukocytes under the treatments with 20mg/20g of Kuei-Pi-Tang administered after irradiation.
为了评估归脾汤作为抗辐射剂的潜在作用，采用了脾脏中骨髓细胞集落形成单位（CFUs）。在ICR品系小鼠组中，进行不同顺序的X射线照射，照射前后连续7天每天腹腔注射10mg/20g或20mg/20g归脾汤。经过不同处理后，从尾尖采集全血以观察白细胞、红细胞和血小板的波动情况。20mg/20g剂量的效果优于10mg/20g剂量。与10mg/20g剂量相比，20mg/20g剂量的归脾汤治疗显示出较低的放射敏感性。注射归脾汤加速了4Gy照射小鼠白细胞、红细胞和血小板血细胞计数的恢复，尤其是照射后给予20mg/20g剂量归脾汤治疗的白细胞。
