Hsu H Y, Yang J J, Lian S L, Ho Y H, Lin C C
School of Technology for Medical Sciences, Kaohsiung Medical College, Taiwan, R.O.C.
J Ethnopharmacol. 1996 Nov;54(2-3):69-75. doi: 10.1016/s0378-8741(96)01450-x.
The herbal formulation Si-Jun-Zi-Tang reduced the decrease of leukocytes, erythrocytes, thrombocytes and hematocrit in irradiated mice. In general, its protection was more effective in leukocytes and thrombocytes than other hematocytes. Protection of bone marrow stem cells by Si-Jun-Zi-Tang was markedly enhanced by increased radiotolerance under the dose ranging from 0 to 5 Gy. This increased radiotolerance led to a prolonged shoulder in the survival curve but did not influence the D0 value. Si-Jun-Zi-Tang exerted a beneficial effect on clinical syndromes such as anemia. From the results in this study, we concluded preliminarily that the most effective concentration with least toxicity was about 20 mg/20 g body weight. At this dose, levels of leukocytes as well as thrombocytes were enhanced significantly after chi-irradiation. Elevation of erythrocytes and hematocrits could also be found but was not significant.
中药方剂四君子汤可减轻辐射小鼠白细胞、红细胞、血小板及血细胞比容的降低。总体而言，其对白细胞和血小板的保护作用比其他血细胞更有效。在0至5 Gy剂量范围内，四君子汤通过提高辐射耐受性显著增强了对骨髓干细胞的保护作用。这种辐射耐受性的提高导致存活曲线的肩区延长，但不影响D0值。四君子汤对贫血等临床症状有有益作用。从本研究结果初步得出，毒性最小的最有效浓度约为20 mg/20 g体重。在此剂量下，χ射线照射后白细胞和血小板水平显著升高。红细胞和血细胞比容也有所升高，但不显著。
