“可溶性”腺苷酸环化酶生成的环磷酸腺苷促进PC12细胞快速迁移。
"Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells.
作者信息
Young Jennifer J, Mehdi Amna, Stohl Lori L, Levin Lonny R, Buck Jochen, Wagner John A, Stessin Alexander M
机构信息
Gateways to the Laboratory Program, Weill Medical College of Cornell University, New York, New York, USA.
出版信息
J Neurosci Res. 2008 Jan;86(1):118-24. doi: 10.1002/jnr.21458.
Abstract
In a model for neuronal movement, PC12 cells undergo fast migration in response to nerve growth factor (NGF) and phorbol ester (PMA). We previously showed that NGF increases intracellular cAMP via activation of soluble adenylyl cyclase (sAC). In this report, we demonstrate that sAC activation is an essential component of NGF- + PMA-induced fast migration in PC12 cells. Interestingly, PMA also raises intracellular cAMP but does so by stimulating transmembrane adenylyl cyclases (tmAC); however, this tmAC-generated cAMP does not contribute to fast migration. Therefore, cells must possess independent pools of cAMP capable of modulating distinct functions.
摘要
在一个神经元运动模型中，PC12细胞在神经生长因子（NGF）和佛波酯（PMA）的作用下进行快速迁移。我们之前表明，NGF通过激活可溶性腺苷酸环化酶（sAC）来增加细胞内cAMP。在本报告中，我们证明sAC激活是PC12细胞中NGF + PMA诱导的快速迁移的一个重要组成部分。有趣的是，PMA也会提高细胞内cAMP，但它是通过刺激跨膜腺苷酸环化酶（tmAC）来实现的；然而，这种由tmAC产生的cAMP对快速迁移没有贡献。因此，细胞必须拥有能够调节不同功能的独立cAMP池。
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