Krunic Aleksandar L, Chen Helen M, Lopatka Keith
Department of Dermatology, University of Illinois at Chicago, 502 Park Avenue, River Forest, IL 60505, USA.
Australas J Dermatol. 2007 Aug;48(3):187-9. doi: 10.1111/j.1440-0960.2007.00379.x.
Cutaneous metastasis from gallbladder cancer is extremely rare. We present a case of signet-ring cell carcinoma of the gallbladder metastatic to the skin in a 38-year-old man. The skin nodules on the face, scalp and perianal area occurred approximately 1 year after the resection of the neoplasm. Skin metastases from gastrointestinal cancers are usually detected around surgical scars or on the abdominal wall, especially in the periumbilical region, and rarely present at other sites. Multiple imaging studies revealed the presence of metastatic bony involvement in the spine and left orbit. Visceral metastases have not been demonstrated in our patient in 20 months of follow up since the initial diagnosis of gallbladder cancer was made. We also briefly discuss other primary and metastatic skin tumours with signet-ring cell morphology.
胆囊癌的皮肤转移极为罕见。我们报告一例38岁男性，其胆囊印戒细胞癌转移至皮肤。面部、头皮和肛周区域的皮肤结节在肿瘤切除后约1年出现。胃肠道癌的皮肤转移通常在手术瘢痕周围或腹壁被发现，尤其是在脐周区域，很少出现在其他部位。多项影像学检查显示脊柱和左眼眶存在转移性骨受累。自最初诊断胆囊癌以来，在20个月的随访中，我们的患者未发现内脏转移。我们还简要讨论了其他具有印戒细胞形态的原发性和转移性皮肤肿瘤。
