Katoh T, Tanaka M, Nimura Y, Kanai M, Nagino M, Ozawa T
Department of Surgery, Faculty of Medicine, University of Nagoya, Japan.
Biochem Int. 1991 May;24(1):107-16.
We have examined the effects of portal branch ligation on liver mitochondrial function and on subsequent extended hepatectomy in rat. In the occluded lobes, mitochondrial function was depressed immediately after the ligation. In the unoccluded lobes, mitochondrial function was enhanced and reached the maximum two days after the ligation. This enhancement was associated with increases in the enzymic activities and subunit amounts of the energy-transducing complexes, and with increase in mitochondrial DNA content. The ligation improved both survival rate and mitochondrial redox state monitored by the ratio of acetoacetate to beta-hydroxybutyrate after hepatectomy. These results suggest that the enhancement of mitochondrial function by portal branch ligation fills the energy demand for liver regeneration.
我们研究了门静脉分支结扎对大鼠肝线粒体功能以及随后扩大肝切除术的影响。在被结扎的肝叶中，结扎后线粒体功能立即受到抑制。在未被结扎的肝叶中，线粒体功能增强，并在结扎后两天达到最大值。这种增强与能量转换复合体的酶活性和亚基数量增加以及线粒体DNA含量增加有关。结扎提高了肝切除术后的存活率以及通过乙酰乙酸与β-羟基丁酸的比率监测的线粒体氧化还原状态。这些结果表明，门静脉分支结扎引起的线粒体功能增强满足了肝脏再生的能量需求。
